SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS

描述：在这份续签建议书中，少校 这项研究的目的是为 有机化学与药物的合成研究 具有生理活性的天然和人造有机化合物，包括 1.孢霉毒素：全合成，局部和整体构象优先， 放射性标记PTX的制备及其亲和力的制备 柱，2.C-和O-糖苷的构象分析：人血 抗原，含6-O-甲基-D-葡萄糖的脂多糖(MGLP)和 3-O-甲基甘露糖(MMPs)和C-海藻糖， 3.化学标尺：脂肪酸及其化合物的构象分析 含离子有机大分子的设计与合成 通道状组装；毛霉毒素的立体化学归属，4。 AAL毒素和伏马菌素的结构鉴定和合成，5. Ni(II)/Cr(II)介导的偶联反应：不对称过程，6. 三脚架配体化学：肠瘤素类似物和其他，和7。 蝙蝠夜蛾毒素和阿拉伯糖的全合成。校长 研究人员指出，有机化学的力量是最大的 通过挑战复杂的系统进行有效扩展，并且许多 医学的进步关键取决于权力的扩大 有机化学的。他进一步表示，这也是他的 目的开发实用高效的某些化合物的合成方法 具有高生理活性的天然产物及其类似物 活性，但不是以可感知的数量从天然 消息来源。他预计这些研究将促进在以下方面的进展 医药。

DESCRIPTION: In this renewal proposal it is stated that the major objective in this research is to make significant contributions to organic chemistry and medicine through synthetic studies on physiologically active natural and man-made organic compounds, including 1. Palytoxin: Total Synthesis, Preferred Local and Global Conformation, Preparation of Radioactively Labelled PTX, and Preparation of Affinity Column, 2. Conformational Analysis of C- and O- Glycosides: Human Blood antigens, 6-O-Methyl-D-glucose containing Lipopolysaccharides (MGLP) and 3-O-methylmannose-containing Polysaccharides (MMP), and C-Trehaloses, 3. Chemical Ruler: Conformational Analysis of Fatty Acids and Their Derivatives; Design and Synthesis of Large Organic Molecules with Ion Channel-like Assemblies; Stereochemistry Assignment of Maitotoxin, 4. Structure Elucidation and Synthesis of AAL toxins and Fumonisins, 5. Ni(II)/Cr(II)-Mediated Coupling Reaction: Asymmetric Process, 6. Tripodal Ligand Chemistry: Enterobactin analogs and others, and 7. Total Synthesis of Batrachotoxin and Aranotin. The principal investigator notes that the power of organic chemistry is most effectively extended by challenging complex systems, and much of the progress of medicine critically depends upon the extension of the power of organic chemistry. He further states that it is also his specific objective to develop practical and efficient syntheses of certain natural products and their analogs which have high physiological activity, but are not available in appreciable amounts from natural sources. He expects that these studies are to stimulate progress in medicine.