NEW CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYNTHESIS

介绍了选择性有机合成的新催化方法。 有机镧系元素和第3族有机金属将被用作 催化剂在广泛的过程中用于构建复合物 有机分子从相当简单，容易获得的前体。 虽然在这一点上所描述的化学反应是集中在更多的 新的合成方法的基本方面，随时可以获得 通过这些方法产生的化合物（其中许多可以合成 手性、非外消旋形式）将提供更有效和经济的 生物活性材料的重要利益， 医药行业。 预计将开发的工艺将 表现出高度的区域选择性和非对映选择性。 利用手性非外消旋有机金属的不对称合成 还将探索催化剂。 已针对五个具体领域 为了学习 这些包括：1）催化氢化反应。 （二） 化学计量的分子间碳化反应。 3)选择性 催化氢化硅烷化和氢化硼化反应。 4)烯烃 胺化反应 5)的催化环低聚反应 二烯、烯炔和多不饱和有机物。 初步目标将是 合成具有显著反应性有机金属配合物， 在上述过程中的催化周转。 这可能需要 在靶向分子中金属和配体的实质性"调节"， 系统. 其次，我们将研究反应中的非对映选择性， 合适的催化剂与手性底物。 一个长期的，非常具有挑战性的 目标将是开发用于以下的手性、非外消旋催化剂： 有机分子的不对称合成。

New catalytic processes for selective organic synthesis are described. Organolanthanides and group 3 organometallics will be utilized as catalysts in a wide range of processes for the construction of complex organic molecules from rather simple, readily available precursors. Although at this point the chemistry described is focused on the more fundamental aspects of the new synthetic methods, ready access to compounds generated by these methods (many of which may be synthesized in chiral, nonracemic form) will provide more efficient and economic means to biologically active materials of vital interest to the pharmaceutical industry. Processes to be developed are expected to exhibit a high degree of regioselectivity and diastereoselectivity. Asymmetric synthesis utilizing chiral, nonracemic organometallic catalysts will also be explored. Five specific areas have been targeted for study. These include: 1) Catalytic hydrogenation reactions. 2) Stoichiometric intermolecular carbometalation reactions. 3) Selective catalytic hydrosilylation and hydroboration reactions. 4) Olefin amination reactions. 5) Catalytic cyclooligomerization reactions of dienes, enynes, and polyunsaturated organics. Initial goals will be to synthesize organometallic complexes exhibiting significant reactivity and catalytic turnover in the processes outlined above. This may require substantial "tuning" of both the metal and the ligand in the targeted systems. Secondly, we will examine diastereoselectivity in reaction of suitable catalysts with chiral substrates. A long-term, very challenging objective will be to develop chiral, nonracemic catalysts for use in asymmetric synthesis of organic molecules.