EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDY

描述：(改编自申请者摘要)流行性感冒 痴呆症项目将弗雷明翰研究的优势带到了 阿尔茨海默病的发病率、先兆和临床表现的研究 疾病(AD)和其他类型的痴呆症。调查人员提议 将本研究扩大到老年人的子女(及其配偶) 最初的弗雷明翰队列是弗雷明翰后代的成员 一群人。 对子代阿尔茨海默病和痴呆症的调查呈现出一种独特的 有机会纵向检查和跟踪其父母的队列 进行了系统的神经学评估，其痴呆症状态 成立了。父母双方的DNA样本的可用性 后代群体和对家庭关系的了解将 促进AD和痴呆症的遗传学研究。 此外，在过去的40年中，在队列中，在20年中 与阿尔茨海默病和痴呆症研究相关的后代风险因素数据 已经系统地和例行地收集了所有主题的资料。这些 包括：个人习惯、病史和家族史、心血管疾病 危险因素和记录的心血管事件和中风事件 它们都是在一份全面的 中风的研究。已经进行了许多血液化学测定 包括TSH，载脂蛋白包括载脂蛋白E亚型， 同型半胱氨酸、叶酸和维生素B12。 开始于考试的弗雷明翰研究中关于认知衰退的研究 1976年，已经确定了阿尔茨海默病和痴呆的患病率和发病率。 受试者已经在家中、疗养院和慢性病医院接受了评估 医院和弗雷明翰研究诊所也是如此。与时俱进 年龄，特别是在有中风或痴呆症的情况下，年龄增加 许多研究对象将需要在他们的住所看到。磁共振成像 将对病例和对照进行扫描，以确定缺血性变化 缺血性改变的数量、位置、大小和位置将是 与痴呆症有关，与神经学和神经学的特定模式有关- 使用标准MRI读数方案的心理表现 由NHLBI的心血管健康研究开发。

DESCRIPTION: (Adapted from Applicant's Abstract) The Epidemiology of Dementia project brings the strengths of the Framingham Study to the study of the incidence, precursors and manifestations of Alzheimer's Disease (AD) and other types of dementia. The investigators propose to extend the present study to the children (and their spouses) of the original Framingham cohort who are members of the Framingham Offspring cohort. The investigation of AD and dementia in the offspring presents a unique opportunity to examine and follow longitudinally a cohort whose parents were systematically evaluated neurologically and whose dementia status was established. The availability of DNA samples for both the parents and offspring cohorts and knowledge of the family relationships will facilitate genetic studies of AD and dementia. In addition, during the past 40 years in the cohort, and 20 years in the offspring, risk factor data pertinent to the study of AD and dementia have been collected systematically and routinely on all subjects. These include: personal habits, medical and family history, cardiovascular risk factors and documented cardiovascular events, and stroke events which have been collected in considerable detail in a comprehensive stroke study.Many blood chemistry determinations have been made including TSH, apolipoproteins including the apo E isoforms, homocyst(e)ine, folate and vitamin B12. The study of cognitive decline in the Framingham Study which began on Exams in 1976, has determined the prevalence and incidence of AD and dementia. Subjects have been evaluated at home, in nursing homes and chronic hospitals as well as in the Framingham Study clinic. With advancing age, particularly in the presence of stroke or dementia, increasing numbers of study subjects will need to be seen at their residence. MRI scans will be performed on cases and controls to identify ischemic changes The number, site, size and location of the ischemic changes will be related to dementia and to specific patterns of neurologic and neuro- psychological performance using a standard MRI reading protocol developed by the Cardiovascular Health Study of the NHLBI.