ADAPTATION OF LINEAR & ANGULAR VESTIBULOOCULAR REFLEXES

申请人研究的长期目标是： 了解人类如何适应前庭疾病的实际目的 为前庭神经痛患者制定更好的物理治疗计划， 紊乱 本提案的具体目标是更多地了解 短期（几分钟到几小时）VOR适应的机制， 正常人 重点是自适应控制1）耳石眼 反射，2）渠道和耳石眼反射的相位，和3） 扭转VOR 申请人将评估错误信号， 线索，以及任何导致适应性表达的预编程反应。 VOR 关于前庭神经系统的这些方面， 生理学和每一个潜在的重要问题， 前庭适应，驱动它的错误信号，以及如何适应 可以在患者中促进补偿。

DESCRIPTION: The long-term goal of the applicant's research is to understand how humans adapt to vestibular disorders with the practical aim of developing better physical therapy programs for patients with vestibular disorders. The specific objective of this proposal is to learn more about the mechanisms underlying short-term (minutes to hours) VOR adaptation in normal humans. The emphasis is upon adaptive control of 1) otolith-ocular reflexes, 2) the phase of the canal and otolith-ocular reflexes, and 3) the torsional VOR. The applicants will evaluate the error signals, contextual cues, and any preprogrammed responses that lead to the expression of adapted VORs. Relatively little is known about these aspects of vestibular physiology and each potentially bears on important issues related to vestibular adaptation, the error signals that drive it, and how adaptive compensation might be promoted in patients.