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NUTRITIONAL STATUS IN RELATION TO HORMONE RELATED CANCER

NUTRITIONAL STATUS IN RELATION TO HORMONE RELATED CANCER
与激素相关癌症相关的营养状况
批准号:
2463908
负责人:
R N HOOVER
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
在乳腺癌、子宫内膜癌和前列腺癌的研究中, 调查膳食摄入量与人体测量学的关系。 在两项关于美国年轻女性乳腺癌的病例对照研究中, 亚裔美国女性,身高是风险的有力预测因素。更高 体重与年轻美国女性的风险降低有关, 最年轻的亚裔美国女性。儿童荷尔蒙水平调查 绝经前对照组的血清雌二醇水平较低。 在体重较胖的女性与较瘦的女性之间,或许可以解释风险降低的原因 这种癌症在年轻、肥胖的女性中的发病率很高。在年长的亚裔美国女性中, 然而,随着最近的肥胖和最近的肥胖,风险稳步增加。 体重增加。此外,肥胖风险的增加被证明是 在一项乳腺癌的前瞻性研究中,与确诊年龄有关, 65岁或以上被诊断肥胖的女性风险最高。回顾 体重与乳腺癌和子宫内膜癌风险的关系表明 避免体重增加和中心体脂堆积 成年可能会降低老年女性患这些癌症的风险。脂肪百分比 饮食中与乳腺癌风险增加无关,但 饮食习惯可能是饮食模式的替代指标,与 美国筛查人群中的乳腺癌风险。高摄入量 研究发现,大豆(主要是豆腐)的摄入量与降低罹患心脏病的风险有关 亚裔美国女性中的乳腺癌。来自以下儿童母亲的信息 对病例和对照组进行了分析,结果表明,她们都是母乳喂养的 在以下情况中,婴儿时期与乳腺癌风险降低有关 年轻的美国女性。与从不饮酒的人相比,高酒精摄入量 与白人和黑人患前列腺癌风险的增加有关 在一项大型病例对照研究中。同样,乳房风险增加 据观察,年轻女性患癌症的原因是大量饮酒, 最近的摄入量比早期的摄入量更重要 句号。
英文摘要
In studies of breast, endometrial, and prostate cancers, the relationships of dietary intakes and anthropometry were investigated. In two case-control studies of breast cancer in young U.S. women and in Asian-American women, height was a strong predictor of risk. Higher weight was associated with decreased risk in the young U.S. women and the youngest Asian-American women. Investigation of hormone levels among premenopausal controls showed that serum estradiol levels were lower among heavy compared with thin women, perhaps explaining the reduced risk of this cancer among young, heavy women. In older Asian-American women, however, risk steadily increased with both recent adiposity and recent weight gain. Further, increased risk with adiposity was shown to be related to age at diagnosis in a prospective study of breast cancer, with the highest risk for heavy women diagnosed at age 65 or older. A review of body weight and risk of breast and endometrial cancers suggests that avoidance of weight gain and accumulation of central body fat in adulthood may reduce risk of these cancers in older women. Percent fat in the diet was not related to increased risk of breast cancer but dietary habits that may be proxies for dietary patterns were related to breast cancer risk in a screening population in the U.S.. High intake of soy, mainly tofu, was found to be associated with reduced risk of breast cancer among Asian-American women. Information from mothers of cases and controls were analyzed and showed that having been breast-fed as an infant was associated with reduced risk of breast cancer among young U.S. women. Compared with never drinkers, high intake of alcohol was related to increased risk of prostate cancer among whites and blacks in a large case-control study. Similarly, increased risk of breast cancer among young women was observed for high intakes of alcohol, with recent intake being more important than consumption at earlier time periods.
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