METHODOLOGY IN REPRODUCTIVE RESEARCH

在此进行的方法学研究的目的是为以下方面做好准备： 大型和/或确定性项目，审查环境的作用， 生殖结果中的毒物。 方法研究可以解决一个问题 困难调查的一部分（如测量的有效性），或 他们可能是一个试点，以突出困难，在未来的研究， 解决，或者它们可能是使用可访问代理的小型研究（而不是 比罕见的环境暴露），以阐明机制， 毒素影响生殖健康。 今年的方法论研究以咸海地区为中心， 确定是否可以从该区域获得足够的信息， 需要进一步调查 我们有两个试点数据集， 描述该地区的生殖结果。 一个数据集的分析是 完全;主要发现是极高的贫血率（99%）， 该地区，以及巨大婴儿的过剩。 第二数据集 已被编码并正在分析中方法论工作 以酒精为原型的生殖流行病学， 日至今

The purpose of the methodology studies undertaken here is to prepare for large and/or definitive projects that examine the role of environmental toxicants in reproductive outcome. Methodology studies may address one part of a difficult investigation (such as validity of measurement), or they may be a pilot to highlight difficulties in a future study to be resolved, or they may be small studies using an accessible agent (rather than a rare environmental exposure) to elucidate mechanisms by which toxins affect reproductive health. This year methodology studies have centered on the Aral Sea region to determine if sufficient information can be obtained from this region to warrant additional investigation. We have two pilot data sets that describe reproductive outcomes in the area. Analysis of one data set is complete; major findings were the extremely high rate of anemia (99%) in the region, and the excess of macrosomic infants. The second data set has been coded and is now being analyzed. Methodologic work in reproductive epidemiology using alcohol as a prototypical agent is ongoing.