MATERNAL CAFFEINE USE IN PREGNANCY OUTCOME

母亲摄入咖啡因在不良妊娠反应发病机制中的作用 妊娠结局有争议。 多项研究发现， 摄入咖啡因的妇女自然流产的风险增加 和胎儿发育迟缓的风险。 然而，其他的， 同样出色的研究也发现咖啡因没有有害作用 消费 此外，一些研究表明，咖啡因 只对吸烟的女性有害。 以前所有关于这个问题的研究都依赖于母亲报告的 咖啡因使用;没有研究使用咖啡因的生物标志物。 这 该项目将首先验证血清咖啡因及其代谢物的使用 作为咖啡因摄入量的标志，然后将研究这些血清标志物， 作为不良妊娠结局的风险因素。 在验证研究中，血清副黄嘌呤被确定为 咖啡因摄入量的可接受标记，本项目的主要部分 将于1997年开始。

The role of maternal caffeine consumption in the pathogenesis of adverse pregnancy outcomes in controversial. Several studies have found that women who consume caffeine are at increased risk of spontaneous abortion and fetal growth retardation compared to non users. However, other, equally well-done studies have found no harmful effects of caffeine consumption. In addition, several studies have reported that caffeine is harmful only among women who smoke. All previous studies of this question have relied on maternally-reported caffeine use; no studies have employed a biomarker for caffeine. This project will first validate the use of serum caffeine and its metabolites as a marker for caffeine intake, and will then study these serum markers as a risk factor for adverse pregnancy outcome. In the validation study, serum paraxanthine was determined to be an acceptable marker for caffeine intake, and the main part of this project will commence in FY 97.