HELICOBACTER INFECTION AND GROWTH OF CHILDREN

描述 儿童幽门螺杆菌感染预后不佳 明白了。几项流行病学研究报告了两者之间的联系 幽门螺杆菌感染和生长迟缓之间的关系，提示存在干扰 儿童发育的关键时期的营养过程。 这些研究在设计上是横断面的，不能澄清时间 关系：感染是导致生长发育迟缓还是 儿童时期的营养问题使宿主更容易感染最初的 感染？这项研究将提供对 假设幽门螺杆菌感染会导致儿童生长发育减退， 特别是在少数群体和服务不足的人群中。360人的队列 西班牙裔儿童，无论男女，年龄都在1-3岁，在日托中心 哥伦比亚卡利，13C尿素呼气幽门螺杆菌感染阴性 基线测试(UBT)，将跟踪2年，以监测他们的生长 每月测量体重和身高。幽门螺杆菌的发病率 每3个月监测一次UBT和粪便H型感染情况。幽门螺杆菌 每月进行一次抗原修复试验。预计结果将确定 幽门螺杆菌感染的暂时性与生长迟缓 评估幽门螺杆菌感染对儿童影响的信息 卫生和有针对性的适当预防战略。

DESCRIPTION The outcomes of Helicobacter pylori infection in children are not well understood. Several epidemiologic studies have reported an association between H. pylori infection and growth retardation, suggesting interference with the nutritional process at critical periods of childhood development. Those studies were cross-sectional in design and cannot clarify the temporal relationship: does infection lead to retarded growth and development or do nutritional problems in childhood make the host more vulnerable to initial infection? This study will provide a prospective evaluation of the hypothesis that H. pylori infection leads to diminished growth in children, especially in minorities and underserved populations. A cohort of 360 Hispanic children of both sexes, ages 1-3 years, attending day care centers in Cali, Colombia, and negative for H. pylori infection by 13C Urea Breath Test (UBT) at baseline, will be followed for 2 years to monitor their growth with monthly measurements of weight and height. The incidence of H. pylori infection will be monitored with UBT every 3 months and by stool-H. pylori antigen retrieval test every month. The results are expected to establish the temporality of H. pylori infection and growth retardation, essential information for evaluating the effects of H. pylori infection on children's health and targeting appropriate preventive strategies.