CV EFFECTS OF SLEEP RELATED BREATHING DISORDERS

我们的长期总体目标是收集基线数据和重复数据 衡量睡眠呼吸紊乱的指标，重点放在两个方面 呼吸事件和觉醒作为决定的自变量 心血管风险。本提案涉及收集 基线数据，预计该项目的续签将 允许获得后续行动。 我们这个项目的主要目标是收集数据，以便进行测试 在关于SRBD和心血管风险关系的几个假设中， 包括高血压和左心室肥厚的发展。其次， 我们将检验这一假设，即睡眠中断和唤醒将是一种 更好地标记睡眠相关呼吸障碍的严重程度 因此，心血管疾病发病率的预测指标比参数更好 源自目前的呼吸监测技术。最后，我们 建议审查和验证历史和行动记录的能力 以多导睡眠图代替全睡眠图作为自变量 心血管结局的风险分析和序贯试验 初始队列中定义的患者组。对该方法的验证 将极大地促进未来的纵向研究，这些研究应该 从目前的数据库中。

Our longterm overall goal is to collect both baseline data and repeated measures characterizing sleep disordered breathing, focusing on both respiratory events and arousal as independent variables in determining cardiovascular risk. The present proposal addresses collecting the baseline data, with the expectation that renewal of this project would allow the follow-up to be obtained. Our primary aim for this project is to collect data allowing the testing of several hypotheses about the relationship of SRBD and CV risk, including the development of hypertension and LV hypertrophy. Secondarily, we will test the hypothesis that sleep disruption and arousal will be a better marker of the severity of sleep related breathing disorders and therefore better predictors of cardiovascular morbidity than parameters derived from current respiratory monitoring techniques. Finally, we propose to examine and validate the ability of history and actigraphy to substitute for full polysomnography as the independent variables in analyses of risk for cardiovascular outcomes and in sequential testing of patient groups defined in the initial cohort. Validation of this approach would greatly facilitate future longitudinal studies which should evolve from the present data base.