Defining pathways that control T cell lifespan for long-term immunity

该项目将研究调节组织驻留记忆T细胞（Trm细胞）寿命的细胞和分子途径，Trm细胞是一种非循环T细胞亚群，在抵抗感染的前线防御中起着至关重要的作用。值得注意的是，Trm细胞存活的时间对免疫持续的时间至关重要。使用尖端的细胞和分子技术，这个项目的预期结果包括识别控制寿命的基因和过程。这对了解免疫的寿命是如何调节的基本知识有很大的帮助。这一认识将有助于未来的免疫治疗应用，例如需要最长免疫持续时间的兽用或人用疫苗

This project will investigate the cellular and molecular pathways regulating lifespan of tissue-resident memory T cells (Trm cells), a non-circulating T cell subset that play a crucial role in the frontline defence against infection. Significantly, how long Trm cells live is paramount to how long immunity is sustained. Using cutting-edge cellular and molecular techniques, the expected outcomes of this project include identification of the genes and processes that control lifespan. This should provide significant benefits in the basic knowledge of how longevity of immunity is regulated. This understanding will be useful for future immunotherapeutic applications, such as veterinary or human vaccines requiring maximal duration of immunity