GENETIC & ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGING

拟议研究的主要目的是利用 国家老龄研究所(AGO4563)的初始投资，其中 1984年推出了唯一的纵向行为遗传分析 在晚年生活中的功能的个体差异。这项研究名为 瑞典收养/双胞胎老龄化研究(SATSA)使用了强大的 双胞胎一起抚养，双胞胎分开阅读的设计，已经成为一种 具有里程碑意义的老年遗传学研究。SATSA现在有机会 为了在十年后通过包含一个 第三波面对面测试(IPT3)和第四波问卷调查 评估(第四季度)。大约600人将在IPT3中进行测试， 2,000名个人将获得第四季度。要收集的纵向数据 在信息技术领域，包括对健康和与健康有关行为的衡量， 营养状况、日常生活能力、功能能力和 认知力。调查问卷阶段包括自我感觉到的应受损害。 与健康相关的结果、个性和环境措施 包括生活事件、社会支持、社会经济地位和 家庭环境。SATSA的强大采用/孪生设计提供了 分析遗传和环境问题的令人信服的基础 对生物行为老化的变化和连续性的贡献。 将SATSA扩展到三个测量场合将实现 与形状有关的研究问题的定量遗传分析 生长曲线，如遗传因素对终端的重要性 功能产能的下降和减少。三个衡量标准 提供更适当的基础，以研究 生物行为领域内和生物行为领域之间的度量关系。因此， 分析还将关注评估以下方面的程度 遗传因素和环境因素在遗传和环境间的关系中起中介作用 老年人的健康、认知和幸福感。更精细的分析 关于发展转折点的病因和机制 有助于纵向稳定和变化将是可能的 包括了第四次机会。预测性关系，例如 生活事件和社会支持对认知和健康的影响 后续场合的结果，也将是研究的对象。

The primary purpose of the proposed research is to capitalize on an initial investment of the National Institute on Aging (AGO4563) which in 1984 launched the only longitudinal behavioral genetic analysis of individual differences in functioning later in life. The study, called the Swedish Adoption/Twin Study of Aging (SATSA), uses the powerful design of twins reared together and twins read apart, and has become a landmark study of gerontological genetics. SATSA now has the opportunity to study this unique sample a decade later through the inclusion of a third wave of in-person testing (IPT3) and a fourth wave of questionnaire assessment (Q4). Approximately 600 individuals will be tested in IPT3, and 2,000 individuals will receive Q4. Longitudinal data to be collected in IPT include measures of health and health-related behavior, nutritional status, activities of daily living, functional capacity, and cognition. The questionnaire phase covers self-perceived impairment due to health-related outcomes, personality, and measures of the environment including life events, social support, socioeconomic status and the family environment. The powerful adoption/twin design of SATSA provides a compelling basis for analyzing issues of genetic and environmental contributions to change and continuity in biobehavioral aging. Extension of SATSA to three measurement occasions will enable quantitative genetic analyses of research issues related to the shape of growth curves, such as the importance of genetic factors for terminal decline and reduction in functional capacity. Three points of measure provide a more appropriate basis for examining structural change in the relationship of measures within and between biobehavioral domains. Thus, analyses will also be concerned with assessing the extent to which genetic and environmental factors mediate the relationship between health, cognition and well-being in the elderly. More refined analyses of the etiology of developmental turning-points and the mechanisms contributing to longitudinal stability and change will be possible with the inclusion of a fourth occasion. Predictive relationships, such as the impact of life events and social support on cognitive and health outcomes at subsequent occasions, will also be the object of study.