ANTITUMOR FIJIAN SPONGE DERIVED KETIDE AMINO ACIDS

产品说明： 生物学上重要的海洋海绵Jaspis coriacea是常见的 在整个印度洋-太平洋地区，斐济的珊瑚礁尤其丰富。的 酮基氨基酸的苯甲酰胺家族是主要的二级 马桑子实体的代谢物，以及几种这样的类似物目前是高浓度的。 NCNPDDG补助金U19 CA 52955的优先级，因为他们 对MDA-435乳腺肿瘤细胞的细胞毒性。FIRCA将协助 更详细地检查J. coriacea和bengamides的努力。 以前的工作已经确定了苯甲酰胺类型的分布 在J. coriacea样品中发现的蛋白质似乎随季节和 海绵的地理位置。虽然这种变化是 建立，导致它的因素还不清楚。研究 提出的将检查化学变化的苯甲酰胺在J。 作为生态因子的函数。

DESCRIPTION: The biologically important marine sponge Jaspis coriacea is common throughout the Indo-Pacific and is especially abundant in Fiji reefs. The bengamide family of ketide-amino acids are the predominant secondary metabolites of J. coriacea, and several such analogs are presently a high priority of the parent NCNPDDG grant U19CA52955 because of their cytotoxicity against MDA-435 breast tumor cells. This FIRCA will assist the effort to examine J. coriacea and the bengamides in greater detail. Previous work has established that distribution of the types of bengamides found in J. coriacea samples appears to vary with the season and with the geographical location of the sponges. Although this variability is established, the factors that cause it are not understood. The research proposed will examine the chemical variation of the bengamides in J. coriacea as a function of ecological factors.