PREVALENCE OF PREMENSTRUAL DYSPHORIC DISORDER

描述(改编自申请人的摘要)：包括 经前焦虑症(PMDD)作为DSM-IV的诊断范畴 一直在激烈辩论，争议的焦点是持续缺乏 对其存在的经验支持。拟议的研究试图提供 基于DSM-IV的PMDD是否存在并具有诊断有效性的证据 研究标准。其他目标是确定1)的流行率 PMDD合并其他精神障碍，2)经前 其他轴1精神障碍的恶化，以及3)既往精神障碍 患有和不患有经前抑郁症的妇女的精神障碍。 2,600名年龄在13岁至55岁之间的女性将 通过概率抽样选择，并跟踪两个月经周期。 一半的受试者将来自圣路易斯MSA，一半的受试者来自 芝加哥海事局。城市和农村的子样本将分别从这两个城市中抽取 地理区域。受试者将被要求完成日常症状 调查问卷，并提供研究期间的每日尿样。 后者将被用来确定周期的阶段。对以下问题的回应 将症状问卷分为阶段性症状问卷，以便症状 可以比较月经后和月经前阶段的严重程度， 根据第一个DSM-IV研究标准。症状严重程度将是 用绝对严重度方法和趋势的Trigg方法进行分析 分析。PMDD的其他DSM-IV研究标准将由 跟踪受试者两个周期，并通过1)干扰措施 功能和2)精神诊断。对功能的干扰 每天都会被测量。精神科面谈将在#年进行 研究开始时受试者的住所(以获得目前和 终身诊断)，并在此后每月(评估 相关精神障碍症状的经前变化)。 将使用RASCH分析来确认PMDD的定义并 建立患有经前抑郁症的女性的个人资料。

DESCRIPTION (Adapted from the Applicant's Abstract): The inclusion of Premenstrual Dysphoric Disorder (PMDD) as a diagnostic category of DSM-IV has been hotly debated with controversy centering on the continued lack of empirical support for its existence. The proposed research seeks to provide evidence on whether PMDD exists and has diagnostic validity based on DSM-IV research criteria. Additional aims are to determine the prevalence of 1) PMDD co-occurring with other psychiatric disorders, 2) premenstrual exacerbations of other Axis 1 psychiatric disorders, and 3) past psychiatric disorders among women with and without a current diagnosis of PMDD. Two thousand six hundred women between the ages of 13 and 55 years will be selected by probability sampling and followed for two menstrual cycles. Half of the subjects will be drawn from the St. Louis MSA and half from the Chicago MSA. Urban and rural subsamples will be drawn from each of the two geographic areas. Subjects will be asked to complete daily symptom questionnaires and provide daily urine specimens for the period of study. The latter will be used to establish phase of cycle. Responses on the symptom questionnaire will be liked to phase of cycle so that symptom severity during the postmenstrual and premenstrual phases can be compared, as per the first DSM-IV research criteria. Symptom severity will be analyzed using the absolute severity method and the Trigg method of trend analysis. Other DSM-IV research criteria for PMDD will be addressed by following subjects for two cycles and via measures of 1) interference with functioning and 2) psychiatric diagnoses. Interference with functioning will be measured daily. Psychiatric interviews will be conducted in subjects' homes at the beginning of the study (to obtain current and lifetime diagnoses) and on a monthly basis thereafter (to assess premenstrual change in the symptoms of relevant psychiatric disorders). Rasch analysis will be used to confirm the definition of PMDD and to establish profiles of women with PMDD.