NONINVASIC OPTICAL SENSOR FOR HEMOGLOBIN MEASUREMENTS

描述（改编自申请人的摘要）：在第一阶段CW光学 证明了应用差分吸收光谱的能力 和多重散射技术来测量血红蛋白 部分。第二阶段的目标是开发一种非侵入性的 实时血液传感器的测量水平的四个主要 血红蛋白部分和血细胞比容。 待测量的部分是 氧合血红蛋白（O2Hb）水平降低或脱氧血红蛋白（RHb）， 碳氧血红蛋白（COHb）和高铁血红蛋白（MetHb）。 它也成为 显然，该方法也可用于估计血细胞比容。 在第二阶段，计划修改和改进第一阶段的算法 结合血细胞比容测量，制造原型设备， 并在临床研究中证明该器械的有效性， 然后探索适合商业仪器的设计。 的 带宽对测量精度的影响将是 考察 它还计划生产一种集成传感器， 无创实时监测红细胞压积和个体Hb 在临床环境中使用。 这种真实的实时无创监测 血红蛋白成分和红细胞压积是非常有吸引力的， 避免了采血，减少了治疗决策时间， 消除了感染的风险。 这种类型的仪器显然 具有商业潜力，应该对各种各样的 卫生保健提供者。 拟议的商业应用：不可用。

DESCRIPTION (Adapted from applicant's abstract): In Phase I CW Optics demonstrated the ability to apply differential absorption spectroscopy and multiple scattering techniques to the measurement of hemoglobin moieties. The objective for Phase II is the development of a noninvasive real-time blood sensor for the measurement of levels of four major hemoglobin moieties and hematocrit. The moieties to be measured are levels of oxyhemoglobin (O2Hb) reduced or deoxyhemoglobin (RHb), carboxyhemoglobin (COHb) and methemoglobin (MetHb). It also became evident that the approach could also be used to estimate hematocrit. In Phase II it is planned to modify and improve the Phase I algorithms to incorporate hematocrit measurement, to manufacture prototype devices and demonstrate the efficiency of this device in a clinical study and then to explore a suitable design for a commercial instrument. The effects of band width on the accuracy of the measurements will be examined. It is also planned to produce an integrated sensor for noninvasive real-time monitoring of hematocrit and the individual Hb components in a clinical setting. Such real time noninvasive monitoring of hemoglobin components and hematocrit is very attractive in that it avoids blood sampling, reduces the therapeutic decision time and also eliminates the risk of infection. This type of instrumentation clearly has commercial potential and should be of interest to an assortment of health care providers. PROPOSED COMMERCIAL APPLICATION: Not available.