EPIDEMIOLOGY OF IMPAIRED COAGULANT BALANCE IN DIABETES

这个项目的目的是确定性质、范围和分子 白人、黑人和西班牙裔纤溶功能受损的机制 和美国印第安人群体关于有或没有 糖尿病。总体目标是确定减值是否 纤溶是糖尿病亚临床和临床血管病变的基础 在有和没有加速微血管疾病的特定人群中。 这个项目的结果应该澄清结果的程度 在实验动物中获得的数据直接与人类的糖尿病有关 研究对象。这项研究对两个主要国家的2400份血浆样本进行了研究 流行病学研究(动脉粥样硬化中的胰岛素抵抗研究 和强心研究)也将有助于解释 临床研究的结果)和血小板活化实验的结果。

This project is designed to determine the nature, extent and molecular mechanisms responsible for impaired fibrinolysis in White, Black, hispanic and American indian populations with respect to the presence or absence of diabetes. The overall objective is to determine whether impairments of fibrinolysis underlie subclinical and clinical vascular disease in diabetes in specific populations with and without accelerated microvascular disease. The results of this project should clarify the extent to which results obtained in experimental animals pertain directly to diabetes in human subjects. This study of 2,400 plasma samples from two major epidemiological studies (the insulin Resistance in Atherosclerosis Study and the Strong heart Study) will also assist in the interpretation of results from clinical studies) and from platelet activation experiments.