SYSTEM FOR LOCALIZING TUMOR MARGINS DURING SURGERY

最近的技术发展和公众对常规乳房X光检查必要性的认识不断提高，导致乳房微小病变的检测大幅增加，这些病变通常是无法触及的。不幸的是，手术工具的发展速度没有跟上诊断工具的发展步伐，切除这些小病变仍然是一个困难、耗时的过程，容易失败。这项建议中描述的系统旨在使外科医生能够在保乳手术和针头定位乳腺活检过程中准确地识别肿瘤边缘的位置。该系统旨在提高这些手术的准确性，并减少因不完全切除或遗漏病变而失败的手术数量。在第一阶段，将建造一个测量距离的原型探头，并在一系列模拟手术切除中进行测试。在第二阶段，将开发该系统的手持式版本，并在体内进行测试。建议的商业应用：经济有效的系统改善乳房保乳手术的结果的商业潜力是显著的。我们的商业化战略是基于将根据该计划开发的技术授权给现有的医疗设备供应商。

Recent technological developments and increased public awareness of the need for routine mammographic screening have resulted in a dramatic increase in the detection of small, often nonpalpable breast lesions. Unfortunately, the pace of development of surgical tools has not kept pace with development of the diagnostic tools and removal of these small lesions remains a difficult, time consuming process that is prone to failure. The system described in this proposal is intended to allow surgeons to accurately identify the position of tumor margins during breast conservation surgery and needle-localization breast biopsy procedures. The system is intended to increase the accuracy of these procedures and reduce the number of surgeries that fall due to incomplete resections or missed lesions. In Phase I, a prototype distance-measuring probe will be constructed and tested in a series of simulated surgical resections. In Phase II, a handheld version of the system will be developed and tested in vivo. PROPOSED COMMERCIAL APPLICATIONS: The commercial potential of a cost-effective system to improve the outcome of breast conservation surgeries is significant. Our commercialization strategy is based on licensing the technology developed under this program to an existing vendor of medical equipment.