课题基金 / 基金详情

EFFICACY AND SAFETY OF ORAL RIDOGREL IN ACTIVE ULCERATIVE COLITIS

EFFICACY AND SAFETY OF ORAL RIDOGREL IN ACTIVE ULCERATIVE COLITIS
口服利多格雷治疗活动性溃疡性结肠炎的疗效和安全性
批准号：
6281700
负责人：
ALAN L. BUCHMAN
金额：
$1.36万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6281700
关键词：
clinical research drug screening /evaluation enzyme inhibitors gastrointestinal agents gastrointestinal disorder chemotherapy human subject human therapy evaluation ulcerative colitis

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相关文献

中文摘要
翻译
溃疡性结肠炎（UC）是一种慢性炎症性疾病， 结肠 患者血栓素A2（TXA2）异常升高 在直肠粘膜、肠道和外周血中产生 单核细胞血栓烷具有促炎作用。 里多格雷 特异性抑制血栓烷合成酶， 通过改善活动性UC患者的临床疾病活动性。 本研究将确定低剂量利多格雷用于 治疗活动性UC。
英文摘要
Ulcerative colitis (UC) is a chronic inflammatory condition involving the colon. Patients have abnormally increased thromboxane A2 (TXA2) production in their rectal mucosa, and in intestinal and peripheral blood mononuclear cells. Thromboxanes have proinflammatory effects. Ridogrel specifically inhibits the enzyme thromboxane synthetase and is accompanied by improvement in clinical disease activity in patients with active UC. This study will determine the safety and efficacy of low dose ridogrel for treatment of active UC.
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