A NEW COMBINATORIAL SYNTHESIZER

这项研究的总体目标是开发一种新的实验室仪器，能够合成和分析“盒式磁带”形式的组合阵列。建议的格式允许在紧凑的体积内方便地合成和分析大型阵列，磁带格式比目前由各种研究人员正在研究的二维“芯片”格式具有显著的处理优势。第一阶段的研究将涉及为磁带/基质/阵列系统开发适当的化学，在磁带上合成模型组合阵列，并通过阵列成员的化学分析和阵列成员的抗体识别来验证合成方法。第一阶段研究的成功完成将证明组合阵列可以用磁带格式合成。然后，第二阶段的研究将集中于开发一种自动合成用户设计的阵列的原型仪器。拟议的商业应用：成功完成拟议的研究将产生一种用于合成和分析组合阵列的新仪器。

The overall objective of this research is to develop a new laboratory instrument capable of both synthesizing and analyzing combinatorial arrays in a "tape cassette" format. The proposed format allows large arrays to be conveniently synthesized and analyzed within a compact volume, The tape format offers significant handling advantages over the two dimensional "chip" format currently under investigation by a variety of researchers. Phase I research will involve developing an appropriate chemistry for the tape/matrix/array system, synthesizing a model combinatorial array on a tape, and validating the synthesis method by chemical analysis of array members, and by antibody recognition of an array member. Successful completion of Phase I research would demonstrate that combinatorial arrays can be synthesized in a tape format. Phase II research would then focus on developing a prototype instrument that automatically synthesizes arrays designed by the user. PROPOSED COMMERCIAL APPLICATIONS: Successful completion of the proposed research would lead to a new instrument for synthesizing and analyzing combinatorial arrays.