AUTOMATED VERIFICATION SYSTEM FOR CONFORMAL RTP AND IMRT

随着患者剂量的增加，3D RTP和IMRT的使用正在增加。这些高科技方法的发展和普遍接受的主要障碍是缺乏可用的方法来验证计划剂量将正确地交付给患者。MGS研究公司开发了组织等效的BANG(R)凝胶，可以记录治疗剂量下电离辐射的完整3D剂量分布的永久图像。利用磁共振成像技术（MRI）可以测量BANG凝胶中的剂量分布，具有很高的空间精度和精度。在验证了BANG凝胶剂量测定在放射治疗中的潜在效用后，MGS研究计划与纽约州立大学石溪分校合作，基于BANG凝胶幻影和MRI的使用，创建一个完全自动化的3-D适形RTP和IMRT验证系统。我们的系统将是唯一可用于此目的的工具，因此我们预计会有相当大的需求。这个项目的长期目标就是提供一个独特的产品包括1)DICOM-RT兼容的软件模块的能力创造3 d剂量数据集从核磁共振扫描的辐射爆炸凝胶幻影与治疗计划的关联数据(阶段I和II), 2)一系列的特别设计的幻影包含爆炸凝胶插入和MRI, CT-sensitive结构(二期),和3)MRI扫描和凝胶分析服务为客户使用爆炸凝胶测试仪(第三阶段)。建议的商业应用：在美国大约有2000家放射肿瘤学诊所。如果其中三分之一的人以3500美元的价格购买验证幻影，以2500美元的价格购买软件，那么潜在的总收入将达到400万美元。如果将该系统用于IMRT动态MLC系统的每月QA，并且每月测试包括使用2个凝胶插入，每个125美元，另外200美元用于MR剂量测定，这将导致每个机构的年收入为5400美元。如果25%的机构（较大的大学中心）遵循这一方针，每年就会有270万美元的额外收入。

The use of 3D RTP and IMRT is increasing for patient dose escalation. The major stumbling block to the growth and universal acceptance of these high-tech methods is the lack of available methods to verify that the planned dose will be delivered to the patient correctly. MGS Research Incorporated has developed tissue-equivalent BANG(R) gels that can record permanent images of complete 3D dose distributions of ionizing radiations at therapeutic doses. Dose distributions in BANG gels can be measured with high spatial accuracy and precision using magnetic resonance imaging (MRI). Having verified the potential utility of BANG gel dosimetry for radiation therapy, MGS Research intends to create, in collaboration with SUNY at Stony Brook, a completely automated 3-D conformal RTP and IMRT verification system based on the use of BANG gel phantoms and MRI. Our system will be the only tool available for this purpose and thus we anticipate a sizeable demand. The long-term goal of this project is to deliver a unique product consisting of 1) DICOM-RT compatible software module capable of creating 3D dose data sets from MRI scans of irradiated BANG gel phantoms and of correlating those with the treatment plan data (Phases I and II), 2) a series of specially designed phantoms containing BANG gel inserts and MRI- and CT-sensitive structures (Phase II), and 3) MRI scanning and gel analysis service for customers using BANG gel dosimeters (Phase III). PROPOSED COMMERCIAL APPLICATIONS: There are approximately 2000 Radiation Oncology clinics in the USA. If 1/3 of them purchase the verification phantom at $3500 and the software at $2500 this yields a potential total revenue of $4,000,000. If the system is used for monthly QA of an IMRT dynamic MLC system and if the monthly testing includes the use of 2 Gel inserts at $125 each and an additional $200 for the MR dosimetry, this leads to an annual revenue of $5400 per institution. If 25% of the institutions (the larger university centers) follow this course of action this leads to an additional annual revenue of $2,700,000 per year.