LOCAL CALCIUM SIGNALING IN CELL PHYSIOLOGY

描述：在过去几年中， 了解细胞内钙信号传导的分子机制 i不同的细胞类型。 最近的技术和概念进步 结果表明，刺激诱发的Ca ~（2+）信号往往局限于高 局部领域的细胞，具有重要意义， 这些信号的产生和功能后果。 国际 “细胞生理学中的局部钙信号传导”研讨会将举行 1998年9月9日至11日，在伍兹霍尔的海洋生物实验室， 马萨诸塞州，传播这一领域的最新进展。 这 会议，这是第52届年度研讨会的一般社会 生理学家，将集中在局部钙的机制， 信号是在细胞内产生的，这些信号的不同后果 细胞功能的信号。 会议将在一个非常成功的 过去用于SGP研讨会的格式。 最新的研究成果 将在四个论坛上介绍与会议主题有关的内容。 1)讲座 该领域的19位领导者将涵盖局部Ca 2+信号传导的各个方面， 包括可兴奋细胞（神经元，肌肉， 神经内分泌细胞）以及不可兴奋的细胞（外分泌细胞， 淋巴细胞、卵母细胞）。 讲座将分五节举行， 每个大约三个小时，将涵盖骨骼中的基本Ca 2+事件 和心肌，通过局部Ca 2+控制离子通道，胞吐Ca 2 + 结构域和突触后信号传导，以及局部Ca 2+对IP的影响 受体和细胞器功能。 2)两张海报将 鼓励所有与会者积极参与， 发言者和与会者讨论了最近的环境保护行动成果。 3)六个短 会谈将致力于最新的成果，并将由年轻的 研究人员，题目从提交给 海报会议以及整个科学界。 4)的 会议将以著名的埃德温·内赫博士的主题演讲结束。 在loca Ca 2+信号转导及其功能领域的先驱和领导者 在细胞生理学中的作用。 这次独特而及时的会议的目标是汇集一个多样化的 一群研究人员讨论和比较了 快速发展的局部Ca 2+信号领域。 出席会议， 将被广泛宣传，预计将有150-250名科学家， 包括研究生、博士后科学家和独立的 研究人员对广泛的信号机制感兴趣， 生理系统。 由于它的跨学科范围，它是 预计会议不仅将教育与会者， 尊重目前的知识状态，但也将发挥重要的作用， 在确定该领域未来研究的新方向方面发挥作用。

DESCRIPTION: Rapid progress has been made over the past several years in understanding the molecular mechanisms of signaling by intracellular calcium i diverse cell types. Recent technical and conceptual advances have revealed tha stimulus-evoked Ca2+ signals are often confined to highly localized domains in the cell, with important implications for both the generation and functional consequences of these signals. An international symposium on "Local Calcium Signaling in Cell Physiology" will be held September 9-11, 1998, at the Marine Biological Laboratory in Woods Hole, Massachusetts, to disseminate the latest advances in this field. This meeting, which is the 52nd Annual Symposium of th Society of General Physiologists, will focus on the mechanisms by which localized calcium signals are generated within cells, and on the diverse consequences of these signals for cell function. The meeting will follow a highly successful format used in the past for SGP Symposia. The latest research findings related to the meeting topic will be presented in four forums. 1) Lectures by 19 leaders in the field will cover aspects of local Ca2+ signaling in diverse systems including both excitable cells (neurons, muscle, neuroendocrine cells) as well as non-excitable cells (exocrine cells, lymphocytes, oocytes). The talks will be arranged in five sessions of roughly three hours each and will cover elementary Ca2+ events in skeletal and cardiac muscle, control of ion channels by local Ca2+, exocytosis Ca2+ domains and postsynaptic signaling, and the influence of local Ca2+ on IP receptors and organellar function. 2) Two poster presentations will encourage active participation by all attendees and promote informal discussion of recen results among speakers and attendees. 3) Six short talks will be devoted to late-breaking results and will be given by younger investigators, with topics to be selected from the abstracts submitted for poster sessions as well as fro the scientific community at large. 4) The conference will end with a keynote lecture by Dr. Edwin Neher, a renowned pioneer and leader in the field of loca Ca2+ signaling and its functional roles in cell physiology. The goal of this unique and timely meeting is to bring together a diverse grou of researchers to discuss and compare the latest findings in the rapidly evolving field of local Ca2+ signaling. Attendance at the meeting, which will be widely publicized, is expected to be 150-250 scientists, including graduate students, postdoctoral scientists, and independent investigators interested in a broad range of signaling mechanisms and physiological systems. Because of it interdisciplinary scope, it is anticipated that the conference will not only educate the attendees with respect to the current state of knowledge, but will also play an important role in identifying new directions for future research in this field.