RUTHENIUM CATALYZED ALKYNE COUPLING REACTIONS

这项研究的长期目标是实现这两个详细的 从机理上认识和开发新的合成方法 不同的炔烃偶联反应的次数。过渡金属- 催化的炔烃偶联反应已广泛应用于 合成多种天然产物。过渡金属 Sigma-乙炔类化合物被认为是重要的中间体 在其中一些反应中的物种。这项研究建议研究 配位不饱和Ru-乙酰的基本反应性 关于烯烃和烯烃的偶联反应的络合物 羰基化合物。这项研究建议对这种机制进行研究。 在这些炔烃偶联反应中。具体计划提交给 不饱和Ru-乙酰的催化活性研究 这些反应中的物种。 金属环戊二烯络合物被广泛认为是关键 多种不同烯烃齐聚反应中的中间体 反应。新形成的红曲环戊二烯配合物如图所示 催化乙炔和烯烃的线性偶联反应。 该提案描述了研究反应性和 杂环戊二烯配合物对环戊二烯的催化活性 线性炔偶联反应。这项研究的具体目标 是为了研究基元反应性和催化活性。 Ru-乙炔和苯并环戊二烯的配合物 ···并建立了其详细的反应机理。 这些反应。

The long term objectives of this research are to achieve both detailed mechanistic understandings and to develop new synthetic methods for a number of different alkyne coupling reactions. Transition metal- catalyzed alkyne coupling reactions have been extensively utilized in the synthesis of a wide range of natural products. Transition metal sigma-acetylide complexes are considered to be important intermediate species in some of these reactions. This research proposes to study the fundamental reactivity of coordinatively unsaturated ruthenium-acetylide complexes toward the coupling reactions of alkynes with alkenes and carbonyl compounds. This research proposes to examine the mechanisms of these alkyne coupling reactions. Specific plans are presented to explore the catalytic activity of unsaturated ruthenium-acetylide species in these reactions. Metallacyclopentadiene complexes have been widely implicated as key intermediate species in a number of different alkyne oligomerization reactions. The newly formed ruthenacyclopentadiene complex was shown to catalyze the linear coupling reactions of acetylenes and olefins. The proposal describes specific plans to study the reactivity and catalytic activity of the ruthenacyclopentadiene complexes towards linear alkyne coupling reactions. The specific goals of this research are to study the fundamental reactivity and catalytic activity of the ruthenium-acetylide and ruthenacyclopentadiene complexes toward the alkyne coupling reactions, and to establish the detailed mechanisms of these reactions.