FASEB SUMMER CONFERENCE ON NEUROIMMUNOLOGY

本申请是对第五届联合会的支持请求， 美国实验生物学学会夏季研究会议 将于1998年7月在俄勒冈州的威尔森维尔举行。 来自不同学科的科学家越来越多地 对免疫系统和神经系统之间的对话感兴趣 系统 过去，这一领域的主要努力来自于 免疫学家试图解释免疫系统如何影响 病理条件下的神经系统行为，如自身免疫性 神经系统疾病。人们对互惠关系知之甚少 神经系统对免疫系统的影响，甚至更少是已知的 关于双向交流。 该主题最近 吸引了神经生物学家的注意， 尤其是中枢神经系统创伤和退行性疾病。 结果它 现在已经很清楚：（a）一些曾经被认为是 免疫系统专有的也由神经系统表达; (b)在免疫系统和神经系统之间有一种交互作用， 在完整和受损的中枢神经系统;和（c）的性质， 对话在某些方面对CNS是独特的，而其他方面可能 对所有组织都是一样的。 此外，该领域的迅速发展使得有必要 重新评估CNS-免疫相互作用的一些基本方面，包括 CNS的解剖学、生理学和功能方面 免疫活动和相互作用。 在过去，对免疫的兴趣 脑部疾病仅限于自身免疫性疾病。 最近，很明显，几乎所有与神经有关的疾病 涉及免疫相关成分作为其发病机制的一部分。 这改变了我们对目前接受的治疗方法的看法。 用于治疗退行性疾病的药物工业 CNS以及CNS创伤的治疗。 基本方面应 包括小胶质细胞在退行性疾病和 自身免疫性疾病，CNS免疫豁免，分化中的小胶质细胞， 它们对CNS的可及性及其在创伤和退行性疾病中的作用 疾病 重要的是要在他们自己的神经免疫学家聚集， 论坛，特别是因为这些进程涉及若干国家的投入， 学科

This application is a request for support for the fifth Federation of American Societies for Experimental Biology Summer Research Conference on Neuroimmunology to be held at Wilsonville, Oregon, in July 1998. Scientists from a variety of disciplines have become increasingly interested in the dialogue between the immune system and the nervous system. In the past, the major effort in this field came from immunologists, who attempted to explain how the immune system affects nervous system behavior under pathological conditions such as autoimmune diseases of the nervous system. Little is known about the reciprocal effect of the nervous system on the immune system and even less is known about the bi-directional communication. This subject has recently attracted the attention of neurobiologists in general, and those working on CNS trauma and degenerative diseases in particular. As a result, it has now become clear that: (a) some components once thought to be exclusive to the immune system are also expressed by the nervous system; (b) there is a cross-talk between the immune system and nervous system, both in the intact and the injured CNS; and (c) the nature of the dialogue is unique in certain aspects to CNS while other aspects might be common to all tissues. In addition, the rapid advances in the field make it necessary to reassess a number of basic aspects of CNS-immune interactions, including anatomical, physiological and functional aspects of the CNS in relation to immune activity and interaction. In the past, interest in immune involvement in brain diseases was restricted to autoimmune diseases. Recently it became evident that almost any nerve-related disease involves an immune-associated component as part of its pathogenesis. This alters our view of therapeutic approaches currently accepted in the pharmaceutical industry for treatment of degenerative diseases of the CNS as well as treatment of CNS trauma. The basic aspects which should be reassessed include the role of microglia in degenerative and autoimmune diseases, CNS immune privilege, microglia in differentiation, their accessibility to the CNS and their role in trauma and degenerative diseases. It is important to assemble neuroimmunologists in their own forum, particularly since these processes involve input from several disciplines.