CATALYTIC PROCESSES FOR SELECTIVE ORGANIC SYTHESIS

描述：(申请人摘要)选择性催化过程 对有机合成进行了描述。有机镧系化合物，第3族 有机金属和4族阳离子络合物将被用作 催化剂在多种工艺中用于构建络合物 有机分子来自相当简单、容易获得的前体。一个 将合成一系列有机金属络合物，展示 过程中显著的反应性、选择性和催化剂周转率 概述。这需要对金属、配体和， 对于阳离子络合物，是指催化剂的反离子。 待开发的工艺预计将表现出高度的 区域选择性和非对映选择性。一个长期目标将是 开发用于不对称合成的手性、非外消旋催化剂 有机分子。首先，要进行的化学反应将是 重点介绍了新的合成方法的基本方面。然而，准备好了 获得由这些方法产生的化合物将提供更有效的 和经济手段，以生物活性材料感兴趣的 制药业。例如，这些反应可以排序为 从简单的开始就显著增加了分子的复杂性 从材料到最终产品。此外，这些方法是 对环境无害，因为它们的处理方式没有副产品 (即，它们以“原子经济”进行)。几种不同的 所有由同一类有机金属催化的区域，一直被 作为研究的目标。包括：1)硅氢化和硼氢化 反应。2)硅基金属化反应。3)烯烃胺化反应。 4)聚烯烃、二烯、二烯等的环化反应。 包括顺序反应，其中环化反应通过以下方式终止 硅化、硼化、氢解或β-氢化物消除。

DESCRIPTION: (applicant's abstract) Catalytic processes for selective organic synthesis are described. Organolanthanides, group 3 organometallics, and group 4 cationic complexes will be utilized as catalysts in a wide range of processes for the construction of complex organic molecules from rather simple, readily available precursors. A family of organometallic complexes will be synthesized exhibiting significant reactivity, selectivity, and catalytic turnover in the processes outlined. This requires substantial "tuning" of the metal, the ligand, and, in the case of cationic complexes, the counterion of the catalyst. Processes to be developed are expected to exhibit a high degree of regioselectivity and diastereoselectivity. A long-term objective will be to develop chiral, nonracemic catalysts for use in asymmetric synthesis of organic molecules. At the outset, the chemistry to be carried out will be focused on fundamental aspects of the new synthetic methods. However, ready access to compounds generated by these methods will provide more efficient and economical means to biologically active materials of interest to the pharmaceutical industry. For example, the reactions can be sequenced to provide a dramatic increase in molecular complexity from simple starting materials to the final products. Furthermore, the methods are environmentally sound in that they proceed in a manner where no byproducts are generated (i.e., they proceed with "atom economy"). Several diverse areas, all catalyzed by the same class of organometallics, have been targeted for study. These include: 1) Hydrosilylation and hydroboration reactions. 2) Silylmetalation reactions. 3) Olefin amination reactions. 4) Cyclization reactions of polyolefins, dieneynes, enediynes, etc. involving sequential reactions wherein the cyclizations are terminated by silylation, boration, hydrogenolysis, or beta-hydride elimination.