EPIDEMIOLOGY OF FRACTURES IN PERSONS OF AGE 45 AND OLDER

描述：（改编自研究者摘要） 人是普遍的，对生活质量有很大的影响。 然而，很少有人知道的流行病学骨折的网站 除髋关节外，或除白色人群外的风险因素 女性该提案描述了一项骨折的病例对照研究， 前臂远端、足部、肱骨近端、骨盆和股骨干 胫骨和腓骨之间的女性和男性年龄45岁及以上，在一个 种族多样的人口。将在4年内确定病例 从凯撒的六个医疗中心的成员期间 北方加州永久医疗护理计划。一个共同 5个病例组均设对照组。控件将被 在相同的4年期间累积的情况下，他们将 从年龄和性别定义的分层中随机选择， 这六个医疗中心的会员最新资讯 通过标准化问卷调查获得潜在危险因素 由训练有素的面试官进行面试。问卷将涵盖 人口统计学特征，病史，骨折史， 功能状态、当前健康状况、下肢神经病变， 视力和听力，人体测量，生殖史，身体 活动，吸烟，饮食的选定方面，选定方面 家庭环境，最近的压力生活事件，社交网络， 认知功能，并立即详细描述事件 周围的裂缝。视力和下肢检查 将应用神经病。将审查医疗记录， 处方药和经历的疾病。骨密度， 将通过双能X射线测量脂肪量和瘦体重 在前臂远端骨折病例样本中进行吸收测定（DEXA） 和控制。统计分析将包括比较 各部位骨折病例特点与对照 组，以及彼此。福尔斯的特征导致 将骨折与对照组中的福尔斯进行比较， 骨折前臂远端和足部骨折的数量应该很大 足以普遍考虑所有种族/民族群体的组合。的 研究人员指出，这项研究应该增加我们的几个方面， 骨折流行病学知识，从而提高我们的能力， 提出预防措施。

DESCRIPTION: (Adapted from Investigator's Abstract) Fractures in older people are common and have a large impact on quality of life. Nevertheless, little is known of the epidemiology of fractures of sites other than the hip, or of risk factors in groups other than white females. The proposal describes a case-control study of fractures of the distal forearm, foot, proximal humerus, pelvis and shaft of the tibia and fibula among females and males of age 45 years and older in an ethnically diverse population. Cases will be identified over a 4-year period from the membership of six medical centers of the Kaiser Permanente Medical Care Program of Northern California. One common control group will be used for the five case groups. Controls will be accrued over the same 4-year period as the cases, and they will be selected at random from within strata defined by age and gender from the membership of these same six medical centers. Most information on potential risk factors will be obtained by a standardized questionnaire administered by trained interviewers. The questionnaire will cover demographic characteristics, medical history, fracture history, functional status, current health status, lower extremity neuropathy, vision and hearing, anthropometry, reproductive history, physical activity, cigarette smoking, selected aspects of diet, selected aspects of the home environment, recent stressful life events, social networks, cognitive function, and a detailed description of the events immediately surrounding the fracture. Tests for visual acuity and lower extremity neuropathy will be applied. Medical records will be reviewed for medications prescribed and illnesses experienced. Bone mineral density, fat mass, and lean body mass will be measured by dual energy x-ray absorptiometry (DEXA) in a sample of cases of distal forearm fracture and of controls. Statistical analysis will include comparing characteristics of cases with fracture of each site with the control group as well as with each other. Characteristics of falls leading to fractures will be compared with falls among the controls not leading to fracture. Numbers of distal forearm and foot fractures should be large enough to generally consider all racial/ethnic groups combined. The investigators state that this study should add to several aspects of our knowledge of fracture epidemiology, and thereby increase our ability to suggest preventive measures.