ORGANIZATION OF AUDITORY CORTEX

哺乳动物的听觉皮质由几个区域组成，这些区域可以 以解剖学和生理学的差异为基础的。 拟议研究的主要目标是在更大程度上确定 详细描述了下面的解剖和生理基础 高等灵长类动物听觉皮质中的信息处理。 具体目标包括：(1)描述皮质、颧骨和 丘脑的三个听觉皮质区域(核、带、 Parabelt)及其各自的细分；(2)推导 基于MULTIONAL的每个区域和分区的色调/功能图 单位对纯音、带通噪声突发和特定物种的响应 发声；以及(3)信息基础理论的表述 在每个听觉区域内和之间进行处理。微电极 测绘，神经解剖连接追踪，建筑分析， 和标准的组织化学染色方法将结合使用 以确定字段之间的边界。平行实验将是 在新世界(OWL)猴子中进行技术优势，以及在旧世界中进行 世界(猕猴)猴子与人类的亲缘关系 人类。基本的前提是听觉系统包括一个 按模块组织和分层的控制区域数组 相互连接，具有并行和串联组件。建议数 研究将提供更好的了解解剖学和 生理基质，在其上的加工和分配 听觉信息是基于。这项工作也将作为一个框架 用于后续成人可塑性和外周恢复的研究 或中枢性听觉障碍。

The mammalian auditory cortex is comprised of several areas which can be distinguished on the basis of anatomical and physiological differences. The major objectives of the proposed research is to determine in greater detail the anatomical and physiological substrates which underly information processing in the auditory cortex of higher primates. Specific goals include: (1) description of the cortical, callosal, and thalamic connections of the three auditory cortical regions (core, belt, parabelt) and their respective subdivisions; (2) derivation of tonotopic/functional maps of each region and subdivision based on multi- unit responses to pure tone, bandpass noise bursts, and species-specific vocalizations; and (3) formulation of a basic theory of information processing within and between each auditory region. Microelectrode mapping, neuroanatomical tracing of connections, architectonic analysis, and standard histochemical staining methods will be used in combination to determine the borders between fields. Parallel experiments will be conducted in New World (owl) monkeys for technical advantages, and Old World (macaque) monkeys for their closer phylogenetic relationship to humans. The underlying premise is that the auditory system includes an array of control areas that are modularly organized and hierarchically interconnected, with parallel and serial components. The proposed studies will provide a better understanding of the anatomical and physiological substrates on which the processing and distribution of auditory information are based. This work will also serve as a framework for subsequent research on adult plasticity and recovery from peripheral or central auditory impairments.