CRYSTALLOGRAPHY OF N TERMINAL DOMAIN OF ROUS SARCOMA VIRUS CAPSID PROTEIN: HIV

我们研究计划的总体目标是增加我们的 对劳斯肉瘤病毒结构和组装的认识 (RSV)，为禽类逆转录病毒。这项工作将补充结构 关于人类免疫缺陷病毒(HIV)的工作在这个和 其他实验室在过去的几年里。在成熟的逆转录病毒中， 逆转录病毒衣壳蛋白形成一个外壳，它包裹着 病毒核糖核酸。这种核心结构的形态是戏剧性的 对于不同的逆转录病毒来说是不同的。然而，它看起来很有可能 所有人的组织都有基本的相似之处 逆转录病毒核心。我们的目标是通过结构性的方式解决这个问题 呼吸道合胞病毒衣壳蛋白的研究。从这项研究和其他研究中我们可以 开始了解衣壳之间的相互作用，以及它们如何 确定核心组装和形态。

The general aim of our research program is to increase our understanding of the structure and assembly of Rous sarcoma virus (RSV), an avian retrovirus. This work will complement the structural work on Human immunodeficiency virus (HIV) carried out in this and other laboratories over the past few years. In the mature retrovirus, the retroviral capsid protein forms a shell, which encapsidates the viral RNA. The morphology of this core structure is dramatically different for different retroviruses. Nevertheless it seems likely that there are fundamental similarities in the organization of all retroviral cores. We aim to address this question by structural studies on the RSV capsid protein. From this and other studies we can begin to understand capsidcapsid interactions, and how they might determine core assembly and morphology.