PANEL STUDY OF AGING, BMI AND HEALTH AMONG MEN & WOMEN

描述(改编自研究人员摘要)：考虑肥胖 国家最重要的公共卫生问题之一，因为 将其与过早死亡和某些类型的发病率联系起来的证据 包括糖尿病、高血压和心血管疾病。 尽管人们注意研究肥胖对发病率的影响 和死亡率，相对较少的研究考察了 与健康相关的生活质量。这项拟议的研究旨在 通过应用累积劣势来解决文献中的这一差距 更好地理解超重可能影响身体健康的理论 在整个生命过程中残疾和自我评估的健康。根据 累积劣势理论，首要的研究问题是：做 肥胖对健康的危害，通过身体质量指数(BMI)评估， 随年龄增长是增加还是减少？为此，我们提出了两项主要建议 待检验的假设和几个补充假设： 假设1.BMI对功能性残疾的影响随着 年龄。(这一假设预计，高BMI将产生更多 生命过程中的异质性和健康不平等)。假设2。 体重指数对健康评估的负面影响随着年龄的增长而增加。(更多 一般来说，这一假设预计高BMI会降低健康评级 并导致生命过程中健康下降的恶性循环)。 这项研究通过两个具有全国代表性的小组对这些假设进行了检验 学习。(一)《国民健康与营养检查调查I》： 流行病学随访研究(NHEFS)是一项为期20年的四波小组研究 成年美国人(基线时N=6931人)。(2)美国人改变生活(ACL) 是对美国成年人进行的为期3年的两波小组研究(基线N=3,617 包括非裔美国人和老年研究对象的过多样本)。二 提出了检验假设的具体目标：(1)检验 男性体重指数与功能障碍的关系 小组研究期间的女性和(2)建立关系模型 体重指数和评估的健康随着时间的推移控制 发病率和功能残疾。统计分析解释了 应用选择偏差模型计算死亡率造成的损耗。

DESCRIPTION (adapted from investigator's abstract): Obesity is considered one of the nation's most important public health problems because of the evidence linking it with premature mortality and certain types of morbidity including diabetes mellitus, hypertension, and cardiovascular disease. Despite the attention given to studying the effect of obesity on morbidity and mortality, relatively little research has examined other dimensions of health-related quality of life. The proposed research is designed to address this gap in the literature by applying cumulative disadvantage theory to better understand how excess body weight may affect physical disability and self-assessed health across the life course. According to cumulative disadvantage theory, the overarching research question is: Do the health disadvantages of obesity, assessed by body mass index (BMI), increase of decrease with age? Toward this end, we propose two main hypotheses and several supplementary hypotheses to be tested: Hypothesis 1. The effect of BMI on functional disability increases with age. (This hypothesis anticipates that high BMI will produce more heterogeneity and health inequality over the life course). Hypothesis 2. The negative effect of BMI on health assessments increases with age. (More generally, this hypothesis anticipates that a high BMI lowers health ratings and leads to a pernicious cycle of health decline over the life course). The research tests these hypotheses with two nationally representative panel studies. (1)The National Health and Nutrition Examination Survey I: Epidemiologic Follow-up Study (NHEFS) is a four-wave, 20-year panel study of adult Americans (N=6,931 at baseline). (2)Americans' Changing Lives (ACL) is two-wave, 3-year panel study of adult Americans (N=3,617 at baseline including over-samples of African-American and elderly subjects). Two specific aims are advanced to test the hypotheses: (1) examine the relationship between body mass index and functional disability among men and women over the duration of the panel studies and (2) model the relationship between body mass index and assessed health over time controlling for morbidity and functional disability. The statistical analyses account for attrition due to mortality by applying selection bias models.