Enduring Effects of Early Adversity on Adult Health?

早期逆境对成人健康的持久影响？

• 批准号: 7630880
• 负责人: KENNETH F. FERRARO
• 金额: $ 26.3万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7630880
• 关键词: Accounting; Adult; Age; American; Attention; Child Abuse; Childhood; Cicatrix; Clinical; Communities; Cost Control; Data; Data Sources; Development; Disadvantaged; Disease; Elderly; Evaluation; Event; Force of Gravity; Future Generations; Health; Healthcare; Inequality; Interview; Life; Life Cycle Stages; Link; Mediating; Mediation; Modeling; Modification; Morbidity - disease rate; Outcome; Patient Self-Report; Perception; Persons; Play; Process; Prospective Studies; Psychophysiologic Disorders; Reporting; Research; Resources; Respondent; Role; Shapes; Surveys; Techniques; Testing; United States; deprivation; design; disability; effective intervention; experience; middle age; psychosocial; public health relevance; socioeconomics; theories

DESCRIPTION (provided by applicant): The study of adult health is being transformed by an emerging body of research linking early- life events and experiences with outcomes in adulthood and later life. The overall aim of this research is to build upon epidemiologic models of the life course to explicate the mechanisms by which multiple forms of early adversity compromise health. Previous research has demonstrated the gravity of early adversity on the life course, but relatively little attention has been given to the situational and reflexive aspects of the self that may shape psychosomatic processes. The proposed research draws upon cumulative inequality theory to examine the role that psychosocial and socioeconomic resources play in mediating the relationship between multiple childhood adversities and adult health. Data for this study come from two waves of the National Survey of Midlife Development in the United States (MIDUS). MIDUS surveyed 3,034 adults (ages 25-74) in 1995, and 2,257 respondents were re-interviewed in 2005, providing a decade of observation and the opportunity to observe incident morbidity, change in disability and self-reported health, and the modification of perceived life trajectories. This study has three specific aims: 1. To identify which early adversities are most consequential to adult health and explicate the accumulation processes associated with early adversity. 2. To examine the extent to which resources and perceptions of life trajectories mediate the relationship between childhood adversity and adult health. 3. To consider whether more positive perceptions of life trajectories reduce the rate of health decline between waves and counteract the noxious effects of early disadvantage. The hypotheses, derived from the above aims, will be tested with a variety of multivariate analytic techniques to estimate direct and indirect effects of early adversity on adult health, with formal tests of mediation. PUBLIC HEALTH RELEVANCE: This research attempts to explicate how childhood conditions shape health conditions during adulthood. Clarifying the link between early disadvantage and adult disease will enable development of effective strategies to reduce health problems for future generations. As healthcare policymakers continue to search for affordable cost- containment strategies, it is becoming increasingly important to understand adult health and illness in a life course perspective.

描述（由申请人提供）：成人健康的研究正在通过一系列新兴的研究来改变，该研究将早期生活事件和经验与成年和后期的结果联系起来。这项研究的总体目的是建立生命课程的流行病学模型，以阐明多种形式的早期逆境损害健康的机制。先前的研究表明，早期逆境在生活过程中的严重性，但是对可能塑造心理过程的自我的情境和反思性方面的关注很少。拟议的研究借鉴了累积不平等理论，以研究心理社会和社会经济资源在介导多种儿童逆境与成人健康之间关系中起作用的作用。这项研究的数据来自美国（MIDUS）全国中年发展调查的两波。 MIDUS在1995年调查了3,034名成年人（25-74岁），2005年对2,257名受访者进行了调查，提供了十年的观察，并有机会观察事件发病率，残疾和自我报告的健康状况的变化，以及感知到感知的生命轨迹的修改。这项研究具有三个特定的目的：1。确定哪些早期逆境最大程度地影响成人健康，并阐明与早期逆境相关的积累过程。 2。检查生活轨迹的资源和看法在多大程度上介导了儿童逆境与成人健康之间的关系。 3。考虑对生命轨迹的更多积极看法是否会降低波浪之间健康衰落的速度，并抵消早期不利之处的有害影响。这些假设将从上述目的中得出，将通过多种多元分析技术进行测试，以估计早期逆境对成人健康的直接和间接影响，并进行正式的调解测试。公共卫生相关性：这项研究试图阐明童年状况如何在成年期间塑造健康状况。澄清早期劣势与成人疾病之间的联系将使制定有效的策略，以减少子孙后代的健康问题。随着医疗保健政策制定者继续寻找负担得起的成本遏制策略，在生活课程的角度了解成人健康和疾病变得越来越重要。