RISK FACTORS FOR INCIDENT ALZHEIMERS DISEASE

描述：（改编自研究者摘要）这是一个修订版， 以前的申请没有得到资助。它建议继续芝加哥 健康与老龄化项目（Health and Aging Project），一项研究， 阿尔茨海默病在6,162名居民中的地理定义，城市， 芝加哥南部的一个双胞胎社区。最近的研究数据 表明阿尔茨海默病的患病率在黑人中高出2.65倍 在调整了年龄、教育程度和APOE基因型后，拟议 这项工作研究了潜在的可改变的风险因素，特别是那些可能 解释风险的种族差异。主要问题是：（1） 血管因素，特别是血压升高，增加了 临床表现阿尔茨海默病本身，除了他们接受的 在预测血管性痴呆风险中的作用，（2）这是否是由 通过小的脑梗死和非梗死相关的白色物质变化，以及 (3)血管因素在多大程度上解释了种族间的风险差异 疾病？次要问题包括： 抗炎药和雌激素，生命早期暴露对风险的影响 以及血管因素预测风险的程度 血管性痴呆 为了实现这些目标，建议进行第二次随访（发生率）数据收集 一个周期将检测阿尔茨海默病发生在三年的时间间隔 自上一周期以来，所有临床评价将包括磁 共振成像和磁共振以及地理学。此外，招生 社区居民的连续年龄组，因为他们达到65岁， 建议使研究报告今后能够审查三个重要问题 现有研究无法检验的问题： 老年痴呆症的发病率随着年龄的增长而变化很大， 信息在多个点在一个较长的时间内，和差异 在不同年龄组的风险因素的发生和影响。

DESCRIPTION: (Adapted from the Investigator's Abstract) This is a revision of a previous application that was not funded. It proposes to continue the Chicago Health and Aging Project (CHAP), a study of incident clinically diagnosed Alzheimer's Disease among 6,162 residents of a geographically defined, urban, biracial community of the south side of Chicago. Recent data from the studies suggest that prevalence of Alzheimer's Disease is 2.65-fold higher among blacks than whites after adjustment for age, education and APOE genotype. The proposed work examines potentially modifiable risk factors, especially ones that might explain racial differences in risk. The primary questions are: (1) whether vascular factors, especially elevated blood pressure, increase risk of clinically manifest Alzheimer's Disease itself, in addition to their accepted role in predicting risk of vascular dementia, (2) whether this is mediated through small brain infarcts and non-infarct related white matter changes, and (3) to what extent do vascular factors account for racial differences in risk of disease? Secondary issues include potential protective effects of anti-inflammatory drugs and estrogens, effects of early life exposure on risk of Alzheimer's Disease, and the extent to which vascular factors predict risk of vascular dementia. To achieve these goals, a proposed second follow up (incidence) data collection cycle will detect Alzheimer's Disease occurring in the three year interval since the previous cycle, and all clinical evaluations will include magnetic resonance imaging and magnetic resonance and geography. In addition, enrollment of successive age cohorts of community residents as they reach age 65 is proposed to enable the study, in the future, to examine three important issues that cannot be examined by existing studies: whether effects of risk factors for Alzheimer's Disease vary greatly with age, the need for exposure information at multiple points over an extended period of time, and differences in the occurrence and effects of risk factors in different age cohorts.