LONGITUDINAL OPTIC NEURITIS STUDY

这项建议是为了对以下人群进行长期跟踪研究 参加视神经治疗试验(ONTT)的患者 在1988至1991年间，一直作为纵向 1992年以来的视神经炎研究(LONS)。ONTT的主要目标是 评价糖皮质激素治疗急性视神经病变的疗效 神经炎。LONS的主要目标是(1)评估 视神经炎后视功能的长期病程及(2) 视神经炎与多发性硬化关系的探讨 硬化症(MS)。这项申请是为了延续 获取有关这两个项目的更多有价值的长期跟踪信息 在这个独特的患者队列中，视觉过程和神经学过程。 从来没有其他研究像这样广泛地收集和评估过 标准化的方法学使如此大量的视神经患者 神经炎。这个队列是通过相当大的努力和成本组建起来的。 目前拟议的研究所涉及的费用与 总体研究成本。从这项研究中得出的信息将具有 视神经疾病患者的治疗和生活质量相关性 神经症。 在该提案的头四年，患者接触将是 通过数据协调中心的电话和邮件进行维护 中心。在第五年，15家隆氏诊所将重新获得认证，并 每名患者都将接受眼科检查、视功能检查 测试和神经学检查，按照目前在 朗斯。这次访问将与每一次10-13年的跟踪调查相吻合 有耐心的。主要手稿计划在眼科和 神经学结果。 90%以上的原始队列仍在后续行动和机制中 已经到位，以确保这一高比率将继续下去，以提供 长期研究的有效结果。

This proposal is to conduct a long-term follow-up study of the cohort of patients who were entered into the Optic Neuritic Treatment Trial (ONTT) between 1988 and 1991 and have been followed as part of the Longitudinal Optic Neuritis Study (LONS) since 1992. The ONTT's primary objective was to assess the efficacy of corticosteroids in the treatment of acute optic neuritis. The LONS' primary objectives are (1) the evaluation of the long-term course of visual function after optic neuritis and (2) investigation of the relationship between optic neuritis and multiple sclerosis (MS). This application is for a continuation of the LONS to acquire additional valuable long-term follow-up information about both the visual course and the neurologic course in this unique patient cohort. No other study has ever assembled and evaluated so extensively with standardized methodology such a large number of patients with optic neuritis. The cohort was assembled through considerable effort and cost. The costs involved in the current proposed study are small compared to the overall study costs. The information emanating from this study will have both therapeutic and quality of life relevance for patients with optic neuritic. For the first four years of the proposal, patient contact will be maintained through phone calls and mailings from the Data Coordinating Center. In the fifth year, the 15 LONS clinics will be recertified and each patient will be seen for an ocular examination, visual function testing, and neurologic examination by protocols currently utilized in the LONS. This visit will coincide with 10-13 years of follow-up for each patient. Major manuscripts are planned for both the ophthalmic and neurologic results. More than 90% of the original cohort remains in follow-up and mechanisms are in place to assure that this high rate will continue so as to provide valid results for the long-term study.