DEVELOPMENT OF (NON) INVASIVE REAL TIME GLUCOSE SENSORS

描述(摘自申请者的摘要)：化学家和医生 将共同开发一部小说，最近 发明了一种基于智能血糖传感器的材料群 聚晶胶体阵列化学传感器 技术他们将在体内开发出一种新颖、灵敏和实用的 传感装置，可持续监测环境中的葡萄糖浓度。 这项工作将涉及1)传感机制的基础研究 IPCCA；2)基于IPCCA的新传感模体的开发 材料；3)体内使用的传感响应的优化；4) 演示了这些设备在皮下和皮下的应用 正常和四氧嘧啶糖尿病兔的眼外血糖感应。这 这项工作将把这项传感技术推进到可以进一步 开发为一种廉价、简单、连续的葡萄糖传感器，用于 人类。

DESCRIPTION (Adapted from applicant's abstract): Chemists and physicians at the University of Pittsburgh will together develop a novel, recently invented glucose sensing group of materials based on the Intelligent Polymerized Crystalline Colloidal Array (IPCCA) chemical sensor technology. They will develop a novel, sensitive and practical in vivo sensing device to continuously monitor the ambient glucose concentrations. The work will involve 1) fundamental studies of the sensing mechanisms of the IPCCA; 2) development of new sensing motifs based on the IPCCA materials; 3) optimization of the sensing response of in vivo use; 4) demonstrations of the utility of these devices for both subcutaneous and extraocular glucose sensing in normal and alloxan diabetic rabbits. This work will advance this sensing technology to the point it can be further developed as an inexpensive, simple, continuous glucose sensor for use in humans.