MODELING MAMMARY CANCERS IN MICE

乳腺癌是一场悲剧，影响着近18万名新确诊的女性，每年导致超过4.3万人死亡。在了解这种疾病的病因和改进治疗方面取得进展的要求之一是开发新的动物模型，在这种模型中可以研究正常的乳腺生物学和所有阶段的癌变。这些工具已经到位，可以为乳腺研究准备新的小鼠模型；需要的是基础和临床研究人员之间就人类癌症发生和发展的分子和肿瘤生物学以及它们的相关性和在小鼠中建模的方法进行对话。杰克逊实验室正在建立一系列关于人类癌症小鼠模型的会议，总的目标是讨论准确的临床前小鼠模型的开发和验证以及它们在转化性癌症研究中的应用。第一次会议(1999年10月5日至8日)将集中讨论乳腺癌的发生，具体目标包括：(1)评价目前模拟小鼠人类乳腺癌的方法；2)描述有关乳腺肿瘤发生的现有假说；3)交流在理解和模拟血管生成和转移过程方面的最新进展；4)比较和对比人类和小鼠乳腺上皮的激素控制；5)讨论新的治疗和预防策略以及测试它们所需的小鼠模型；6)提供在解释和比较小鼠和人类的组织病理学方面的经验；7)讨论社区所需的信息和其他资源；以及8)准备会议的在线会议记录。

Breast cancer is a tragedy affecting nearly 180,000 newly diagnosed women and killing more than 43,000 each year. One of the requirements for progress in understanding the etiology and improving the treatment of this disease is the development of new animal models in which normal mammary gland biology and all stages of carcinogenesis can be investigated. The tools are in place to prepare new mouse models for mammary gland research; what is needed is a dialog between basic and clinical researchers about the molecular and tumor biology of human cancer initiation and progression and their correlates and approaches to modeling in mice. The Jackson Laboratory is establishing a series of meetings on mouse models for human cancers with the overall goal of discussing the development and validation of accurate preclinical mouse models and their use in translational cancer research. The first meeting, (October 5-8, 1999) will focus on mammary carcinogenesis with the specific objectives of: l) evaluating current approaches to modeling aspects of human mammary cancer in mice; 2) delineating current hypotheses regarding oncogenesis in the mammary gland; 3) communicating recent advances in understanding and modeling processes of angiogenesis and metastasis; 4) comparing and contrasting the hormonal control of mammary epithelium in human and mouse; 5) discussing novel therapeutic and preventative strategies and mouse models needed to test them; 6) providing experience in interpreting and comparing histopathology in mouse and human; 7) discussing informational and other resources needed by the community; and 8) preparing an online proceedings of the meeting.