TOXICOLOGIC EFFECTS OF AIR POLLUTANTS ON LUNG DEFENSE

该项目涉及的毒理学影响的检查， 反复暴露于硫酸雾、二氧化氮或臭氧中， 肺的非特异性防御机制，使用兔子作为动物 模型 检查的基本机制是反射性支气管收缩， 从气管支气管树和肺泡的粘液纤毛清除 巨噬细胞介导的从呼吸区的清除。 间隙 使用放射性标记的示踪气溶胶在未镇静的动物身上进行研究。 将在体外检查巨噬细胞的特定功能方面 在体内暴露后。 此外，肺组织学分析 组织将被执行。 巨噬细胞和组织测定的结果将 与总体清除效率有关。 本研究将提供 关于三种主要环境空气污染物在改变 重要的肺防御;这种变化可能是早期阶段， 进展为慢性阻塞性肺疾病。

This project involves examination of the toxicologic effects of single and repeated exposures to sulfuric acid mist, nitrogen dioxide, or ozone upon nonspecific defense mechanisms of the lung, using the rabbit as an animal model. The basic mechanisms examined are reflex bronchoconstriction, mucociliary clearance from the tracheobronchial tree, and alveolar macrophage-mediated clearance from the repiratory region. Clearance is studied in unsedated animals using radioactively tagged tracer aerosols. Specific functional aspects of macrophages will be examined in vitro following in vivo exposures. In addition, histological analyses of lung tissue will be performed. Results of the macrophage and tissue assays will be related to overall clearance effectiveness. This study will provide information on the role of three major ambient air pollutants in altering essential lung defenses; such changes may be early stages in the progression towards chronic obstructive lung disease.