PET AND THE FUNCTIONAL NEUROANATOMY OF DEPRESSION

这是对ADAMHA SDAC的请求。在被请求人的任期内 获奖，实现以下职业发展目标是 预期：a)发展作为功能性脑成像的能力 研究人员使用正电子发射断层扫描(PET)。B)建立 具有神经生理学评估的专业知识(使用正电子发射计算机断层扫描) 人类情感的病理形式。该实验计划提出了 实现这些目的包括：1)将正电子发射计算机断层扫描技术应用于核磁共振研究 病理情绪状态，通过a)根据以下方面描述病理生理学 局部脑血流量(RCBF)或葡萄糖代谢(RCMRglu)，b 评价药物对RCBF和rCMRglu的影响 情感性疾病的特质与状态生理异常 对有症状和无症状状态的患者进行成像。四 病理性情绪状态将被研究--单相抑郁和双相抑郁 情感障碍-抑郁和低躁狂期，恶劣心境障碍，以及 老年重度抑郁症。2)研究神经生理学相关因素 使用：a)功能激活范例(其 比较对照和激活状态下受试者体内rCBF的变化) 旨在涉及悲伤的体验，以及b)调查 伴随的生理变化，简单的丧亲作为一种模型 反应性抑郁。这样的知识将是照亮 病理性情绪中发现的局部异常的意义 各州。3)旨在更准确地比较患者的测试方法 和控制PET图像，并学习应用其中的算法 将正电子发射计算机断层扫描和核磁共振成像数据相互关联，以矫正区域性萎缩。

This is a request for an ADAMHA SDAC. During the tenure of the requested award, achievement of the following career development objectives is anticipated: A) Developing competence as a functional brain imaging researcher utilizing positron emission tomography (PET). B) Establishing expertise in the neurophysiologic assessment (with PET) of normal and pathologic forms of human emotion. The experimental program proposed to accomplish these ends consists of: 1) Applying PET to the study of pathologic emotional states, by a) delineating pathophysiology in terms of regional cerebral blood flow (rCBF) or glucose metabolism (rCMRglu), b) assessing effects of medications on RCBF and rCMRglu, C) distinguishing trait versus state physiologic abnormalities in affective illness by imaging patients in both symptomatic and asymptomatic states. Four pathologic mood states will be studied - unipolar major depression bipolar affective disorder-depressed and hypomanic phases, dysthymic disorder, and elderly major depression. 2) investigating the neurophysiologic correlates of normal human emotion using: a) functional activation paradigms (which compare intrasubject rCBF change between control and activated states) designed to involve the experience of sadness, and b) investigating physiologic changes accompanying, uncomplicated bereavement as a model for reactive depression. Such knowledge will be critical for illuminating the significance of regional abnormalities identified in pathological mood states. 3) Testing methodology intended to more accurately compare patient and control PET images, and learning application of algorithms which correlate PET and MRI data for correction for regional atrophy.