PET AND THE FUNCTIONAL NEUROANATOMY OF DEPRESSION

这是一个ADAMHA SDAC的请求。 在所请求的任期内， 获得奖励后，实现以下职业发展目标， 预期：A）发展作为功能性脑成像的能力 研究人员利用正电子发射断层扫描（PET）。 B）建立 在神经生理学评估（PET）的专业知识， 人类情感的病理形式 该实验方案提出， 实现这些目标包括：1）将PET应用于研究 病理性情绪状态，通过a）从以下方面描述病理生理学： 局部脑血流量（rCBF）或葡萄糖代谢（rCMRglu），B） 评估药物对RCBF和rCMRglu的影响，C）区分 情感性疾病中的特质与状态生理异常 对有症状和无症状状态的患者进行成像。 四 将研究病理性情绪状态--单极重性抑郁双相 情感障碍-抑郁和轻躁狂阶段、心境恶劣障碍和 老年抑郁症2)研究神经生理学相关因素 正常的人类情感使用：a）功能激活范式（ 比较对照和激活状态之间的受试者内rCBF变化） 目的是涉及悲伤的经验，和B）调查 生理变化伴随，简单的丧亲作为一个模型， 反应性抑郁 这些知识对于阐明 病理性情绪中区域异常的意义 states. 3)测试方法旨在更准确地比较患者 和控制PET图像，并学习算法的应用， 将PET和MRI数据相关联，以校正局部萎缩。

This is a request for an ADAMHA SDAC. During the tenure of the requested award, achievement of the following career development objectives is anticipated: A) Developing competence as a functional brain imaging researcher utilizing positron emission tomography (PET). B) Establishing expertise in the neurophysiologic assessment (with PET) of normal and pathologic forms of human emotion. The experimental program proposed to accomplish these ends consists of: 1) Applying PET to the study of pathologic emotional states, by a) delineating pathophysiology in terms of regional cerebral blood flow (rCBF) or glucose metabolism (rCMRglu), b) assessing effects of medications on RCBF and rCMRglu, C) distinguishing trait versus state physiologic abnormalities in affective illness by imaging patients in both symptomatic and asymptomatic states. Four pathologic mood states will be studied - unipolar major depression bipolar affective disorder-depressed and hypomanic phases, dysthymic disorder, and elderly major depression. 2) investigating the neurophysiologic correlates of normal human emotion using: a) functional activation paradigms (which compare intrasubject rCBF change between control and activated states) designed to involve the experience of sadness, and b) investigating physiologic changes accompanying, uncomplicated bereavement as a model for reactive depression. Such knowledge will be critical for illuminating the significance of regional abnormalities identified in pathological mood states. 3) Testing methodology intended to more accurately compare patient and control PET images, and learning application of algorithms which correlate PET and MRI data for correction for regional atrophy.