COCHLEAR PROSTHESIS

这项研究包括五个相互关联的项目，代表一个 综合方法研究具有基础和临床意义的问题 人工耳蜗术的发展和优化应用。该计划是 跨越多个基础科学的多学科方法 学科包括解剖学、听力学、人类心理物理学、动物 心理物理学、生理学和工程学/生物物理学，并将这些 耳鼻喉科的临床问题。美国医学会的总体临床目标 计划的目的是制定措施，协助挑选候选人 植入，这将指导植入和康复策略 优化植入物带来的好处，并做出贡献 更好的人工耳蜗术。基本目标包括提高对 这些措施背后的机制以及假体的描述 在耳蜗生物物理水平上的作用，编码和 中枢神经系统的加工、外周和中枢听觉的结构 结构和感知。这些项目包括心理物理研究 猴子和豚鼠的听力；电流和电流的生物物理研究 内耳的分布；编码和编码的生理学研究 电诱发听觉活动的处理.解剖研究 耳聋对周围和中枢听觉结构的影响 并随着听觉通路的电激活而减少； 和人类对知觉依赖的心理物理研究 刺激的时空特征。这些研究的结果 研究将与人类临床植入研究和 耳鼻咽喉科耳蜗科正在进行的服务计划 假体计划(现在是美国最大的)。这是一项 研究可以提供关于心力衰竭机制的基础知识 作为人工耳蜗术益处的基础的听觉系统 以及对基本听觉系统功能的新见解。

This research includes five interrelated projects representing an integrated approach to questions of basic and clinical significance for the development and optimal application of cochlear prostheses. The program is a multi-disciplinary approach that cuts across a number of basic science disciplines including anatomy, audiology, human psychophysics, animal psychophysics, physiology, and engineering/biophysics and integrates these with clinical issues from Otolaryngology. Overall clinical goals of the program are to develop measures to assist in selection of candidates for implantation and that will guide implantation and rehabilitation strategies to optimize the benefits derived from the implant and to contribute to better cochlear prostheses. Basic goals include an improved understanding of the mechanisms underlying these measures and a description of prosthesis function at levels of the biophysics of the cochlea, encoding and processing in the CNS, structure of peripheral and central auditory structures, and perception. The projects include psychophysical studies of hearing in monkey and guinea pigs; biophysical studies of current flow and distribution in the inner ear; physiological studies of the encoding and processing of electrically evoked auditory activity; anatomical studies of the consequences of deafness on peripheral and central auditory structures and their reduction with electrical activation of the auditory pathways; and human psychophysical studies of the dependency of perception on spatial-temporal characteristics of stimulation. The results of these studies will be integrated with the human clinical implant research and service program ongoing in the Department of Otolaryngology's Cochlear Prosthesis Program (now the largest in the United States). This program of research can provide fundamental knowledge about the mechanisms of the auditory system that underlie benefits provided by the cochlear prosthesis as well as new insights into basic auditory system function.