DNA exhibits new self-assembled structures due to clustered DNA methylation

该项目旨在开发一种技术，通过直接询问DNA聚合物在其天然状态下的物理性质来研究DNA中详细的表观遗传模式。表观遗传学控制着基因和遗传程序在生命系统中的开启或关闭。该项目将建立在最近发现的基础上，即天然DNA聚合物的关键物理特性受到生物体产生的表观遗传模式的强烈影响。通过充分了解这一现象，该项目旨在为表观遗传学研究提供新的工具，在生命科学，生物技术和纳米技术中具有广泛的潜在应用。

This project aims to develop a technology to investigate detailed epigenetic patterns in DNA by directly interrogating the physical properties of DNA polymers in their native state. Epigenetics controls whether genes and genetic programs are turned on or off in living systems. The project will build on a recent discovery that key physical properties of native DNA polymers are strongly influenced by epigenetic patterns created by living organisms. By fully understanding this phenomenon, this project aims to provide new tools for the study of epigenetics with broad potential applications in the life sciences, biotechnology and nanotechnology.