BEHAVIORAL NEUROSCIENCE AND SCHIZOPHRENIA

我们在这份修订后的神经科学中心申请中的计划 精神分裂症(CNS)是合作的自然产物 在基础和临床的大型社区中存在的相互作用 校园里的神经学家。鉴于精神分裂症患者的异质性 综合症和对其发病机制缺乏共识，我们 相信多样化和多学科的方法是最 适当的概念视角将神经科学和 精神分裂症。因此，基础和临床的科学领域 本申请书中提议的调查故意包括广泛的 动物脑功能研究的主题和方法 和人类受试者。该中心将由临床核心部分组成；以及 四个主要的研究项目。临床核心将承担 招募、临床评估、管理、维护和随访 当前和未来研究所需的临床和正常对象， 包括与种子资金计划有关的资金。它会的，在 此外，进行神经心理、自身免疫、睡眠、认知和 治疗调查。提出了四个重点研究计划 包括对网络变化的神经生理学研究 大鼠海马神经元的特性、神经解剖学研究 猴的前额叶皮质，神经生理学研究 多巴胺能神经元及多巴胺释放的神经化学研究 大鼠前脑及临床活体核磁共振结构和功能的研究 精神分裂症患者脑内代谢的变化。可能是这样的 预计，某些共同的主题贯穿于这四个节目。为 例如，额叶皮质功能障碍在脑梗塞病因中的作用 在节目2、3和4中假定患有精神分裂症，生物学上的 典型和非典型抗精神病药物的作用与这四种药物都有关 程序。我们投资这家企业的最大希望和理由 是在参与性的科学和互惠教育活动中 基础神经学家和临床研究人员之间的关系 一个这样的中心，以及从如此富有成效的 新假设和新模式的协同互动 这些共同关心的问题以及下一步的发展 一代又一代的调查员将接受足够的培训和 具备在基础和临床之间建立成功联系的能力 与严重精神障碍相关的神经科学。

Our plans in this revised application for the Center for Neuroscience in Schizophrenia (CNS) represent a natural outgrowth of the collaborative interactions that exist within the large community of basic and clinical neuroscientists on campus. Given the heterogeneity of the schizophrenic syndrome and the lack of consensus regarding its pathogenesis, we believe that a diverse and multidisciplinary approach is the most appropriate conceptual perspective for relating neuroscience and schizophrenia. Consequently, the scientific areas of basic and clinical investigations proposed in this application deliberately include a wide range of topics and approaches to the study of brain function in animal and human subjects. The Center will consist of the Clinical Core; and four major research programs. The Clinical Core will undertake the recruitment, clinical assessment, management, maintenance, and follow-up of clinical and normal subjects required for current and future studies, including those associated with the Seed Money Program. It will, in addition, conduct neuropsychological, autoimmune, sleep, cognitive, and treatment investigations. The four key research programs proposed encompass neurophysiological studies of the alterations in the network properties of hippocampal neurons in rats, neuronanatomical studies of the prefrontal cortex in monkeys , neurophysiological studies of dopaminergic neurons and neurochemical studies of dopamine release in rat forebrain and clinical in vivo NMR assessment of structural and metabolic changes in the brains of schizophrenic patients. As might be expected, certain common themes run through the four programs. For example, a role for frontal cortical dysfunctions in the etiology of schizophrenia is presumed in Programs 2, 3, and 4 and the biological actions of typical and atypical neuroleptics are relevant to all four programs. Our greatest hope and reason for investment in this venture is in the participatory scientific and mutual educational activities between basic neuroscientists and clinical investigators that we see in a Center of this kind, and the emergence from such productive collaborative interactions of new hypotheses and modes for approaching these issues of joint concern, as well as the development of the next generations of investigators who will be sufficiently will trained and equipped to develop successful links between basic and clinical neuroscience relevant to major mental disorders.