Delineating the neural basis of sequence memory in the rat

我们记住事情发生的顺序，或者我们在日常生活中遇到物品的顺序的能力是我们记忆的基本部分。例如，当我们从一个地方旅行到另一个地方时，记住路线的一种方法是回忆我们沿着经过的一系列地标。同样，当我们叙述一个个人经历或事件时，任何一个情节都将涉及一系列以特定顺序发生的事件。顺序信息不仅对回忆过去很重要，而且对规划和组织未来行为也至关重要。这个假设是，序列记忆依赖于三个关键的大脑区域，即嗅周皮层、内侧前额叶皮层和海马，然而每个区域可能对序列记忆做出不同的贡献，这取决于序列中要记住的项目的数量和位置。为了验证这一假设，我们将联合收割机结合最先进的分子生物学技术与特定的行为任务，分离不同类型的序列信息，可以使用。我们还将探讨的假设，即嗅周皮层，内侧前额叶皮层和海马必须共同努力，以形成一个神经回路在学习过程中的一系列项目，以及存储这些信息的能力取决于一个特定的分子，CREB细胞核内。这项研究的结果最终将使我们更好地了解我们如何能够学习和存储大脑中的记忆信息。

Our ability to remember the order in which things happen, or the order in which we encounter items in our daily lives is a fundamental part of our memory. For example when we travel from one place to another, one way to remember our route is to recall the series of landmarks we pass along the way. Similarly when we recount a personal experience or event, any episode will involve a sequence of events occurring in a particular order. Not only is sequential information important for recalling the past, but it is also crucial for planning and organising future behaviour. The hypothesis of this proposal is that sequence memory depends on three key brain regions, the perirhinal cortex, the medial prefrontal cortex and the hippocampus, however each region may make a different contribution to sequence memory depending on the number and position of the to-be-remembered items in the sequence. To test this hypothesis we will combine state-of-the art molecular biology technologies with specific behavioural tasks that isolate the different types of sequence information which can be used. We will also explore the hypothesis that the perirhinal cortex, medial prefrontal cortex and hippocampus must work together to form a neural circuit during the learning of a sequence of items, and that the ability to store this information depends on a specific molecule, CREB within the nucleus of cell. The results of this research willl ultimately allow a greater understanding of how we are able to learn and store memory information in the brain.