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Understanding the neural basis of recognition memory in the rat: A functional analysis

了解大鼠识别记忆的神经基础：功能分析

基本信息

批准号：
BB/E010407/1
负责人：
Clea Warburton
金额：
$ 51.34万
依托单位：
University of Bristol
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FE010407%2F1
关键词：
Understanding neural basis recognition memory

项目摘要

Recognition memory is essential to every day life. It involves our ability to judge whether or not we have encountered a stimulus previously. To make these judgements we are able to use a range of different memory processes. For example, we can make one type of judgements if a stimulus is completely new, i.e. never been seen before; we can make a different type of judgement if the stimulus is familiar, depending on whether we have seen it quite recently, or a long time ago; finally and we can make a third type of recognition memory judgements based on whether we have seen a stimulus within a particular environment, location or context. The hypothesis of this proposal is that these different memory processes are controlled by different regions of the brain, the perirhinal cortex, the prefrontal cortex and the hippocampus, potentially operating in a network. The aim of the experiments is firstly to understand which of these brain regions involved in which type of memory process, and secondly to investigate whether these brain regions are co-operating within a memory system. In addition we plan to investigate whether the neurotransmitter glutamate is important for communication between cells in the particular regions of the brain during the processing of information necessary for normal recognition memory function.

认知记忆是日常生活中必不可少的。它涉及到我们判断之前是否遇到过刺激的能力。为了做出这些判断，我们可以使用一系列不同的记忆过程。例如，如果一个刺激是全新的，即以前从未见过，我们可以做出一种类型的判断;如果刺激是熟悉的，我们可以做出不同类型的判断，这取决于我们是最近还是很久以前见过它;最后，我们可以根据我们是否在特定的环境，位置或上下文中看到过刺激来做出第三种类型的识别记忆判断。这个提议的假设是，这些不同的记忆过程是由大脑的不同区域控制的，这些区域包括嗅周皮层、前额叶皮层和海马体，它们可能在一个网络中运行。实验的目的首先是了解哪些大脑区域参与哪种类型的记忆过程，其次是调查这些大脑区域是否在记忆系统中合作。此外，我们计划研究神经递质谷氨酸是否对大脑特定区域的细胞之间的通信很重要，在正常识别记忆功能所需的信息处理过程中。