Understanding the neural basis of recognition memory in the rat: A functional analysis

了解大鼠识别记忆的神经基础：功能分析

• 批准号: BB/E010407/1
• 负责人: Clea Warburton
• 金额: $ 51.34万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FE010407%2F1
• 关键词: Understanding; neural; basis; recognition; memory

Recognition memory is essential to every day life. It involves our ability to judge whether or not we have encountered a stimulus previously. To make these judgements we are able to use a range of different memory processes. For example, we can make one type of judgements if a stimulus is completely new, i.e. never been seen before; we can make a different type of judgement if the stimulus is familiar, depending on whether we have seen it quite recently, or a long time ago; finally and we can make a third type of recognition memory judgements based on whether we have seen a stimulus within a particular environment, location or context. The hypothesis of this proposal is that these different memory processes are controlled by different regions of the brain, the perirhinal cortex, the prefrontal cortex and the hippocampus, potentially operating in a network. The aim of the experiments is firstly to understand which of these brain regions involved in which type of memory process, and secondly to investigate whether these brain regions are co-operating within a memory system. In addition we plan to investigate whether the neurotransmitter glutamate is important for communication between cells in the particular regions of the brain during the processing of information necessary for normal recognition memory function.

识别记忆对于日常生活至关重要。它涉及我们判断我们以前是否遇到过刺激的能力。为了做出这些判断，我们能够使用一系列不同的内存过程。例如，如果刺激是全新的，即从未见过的，我们可以做出一种判断。如果刺激很熟悉，我们可以做出不同类型的判断，具体取决于我们最近还是很久以前看到的刺激。最后，我们可以根据我们是否在特定环境，位置或上下文中看到刺激，进行第三种识别记忆判断。该建议的假设是这些不同的记忆过程受大脑的不同区域，周围皮层，前额叶皮层和海马的控制，可能在网络中运行。实验的目的首先是要了解这些大脑区域中的哪些是在哪种内存过程中，其次是研究这些大脑区域是否在存储系统中合作。此外，我们计划研究神经递质谷氨酸对于在正常识别记忆函数所需的信息过程中处理在大脑特定区域之间的细胞之间是否重要。

项目成果

A critical role for long-term potentiation mechanisms in the maintenance of object recognition memory in perirhinal cortex revealed by the infusion of zeta inhibitory pseudosubstrate.

• DOI: 10.3389/fnbeh.2022.970291
• 发表时间: 2022
• 期刊: Frontiers in behavioral neuroscience
• 影响因子: 3

What pharmacological interventions indicate concerning the role of the perirhinal cortex in recognition memory.

• DOI: 10.1016/j.neuropsychologia.2012.07.034
• 发表时间: 2012-11
• 期刊: Neuropsychologia
• 影响因子: 2.6
• 作者: Brown MW;Barker GR;Aggleton JP;Warburton EC
• 通讯作者: Warburton EC

The medial dorsal thalamic nucleus and the medial prefrontal cortex of the rat function together to support associative recognition and recency but not item recognition.

• DOI: 10.1101/lm.028266.112
• 发表时间: 2012-12-21
• 期刊: Learning & memory (Cold Spring Harbor, N.Y.)
• 作者: Cross L;Brown MW;Aggleton JP;Warburton EC
• 通讯作者: Warburton EC

When Is the Hippocampus Involved in Recognition Memory?

• DOI: 10.1523/jneurosci.6413-10.2011
• 发表时间: 2011-07-20
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Barker, Gareth R. I.;Warburton, Elizabeth C.
• 通讯作者: Warburton, Elizabeth C.

Object-in-place associative recognition memory depends on glutamate receptor neurotransmission within two defined hippocampal-cortical circuits: a critical role for AMPA and NMDA receptors in the hippocampus, perirhinal, and prefrontal cortices.

• DOI: 10.1093/cercor/bht245
• 发表时间: 2015-02
• 期刊: Cerebral cortex (New York, N.Y. : 1991)
• 作者: Barker GR;Warburton EC
• 通讯作者: Warburton EC