ENVIRONMENTAL FACTORS AS DETERMINANTS OF CHILDHOOD ATOPY

本研究的目的是前瞻性地评估 空气中过敏原暴露强度与接触强度的关系 和过敏敏感性的发展(生产 80名儿童中的过敏原特异性IgE) 出生到四岁。被选中学习的孩子将 因脐带血升高而患特应症的遗传风险很高 免疫球蛋白浓度大于或等于0.6u/ml。 五种吸入性过敏原的数量，年轻人对 儿童通常会变得敏感，将被测量在 每月从每个孩子的卧室里采集空气样本，使用一个小的 容量空气采样器，以及酶联免疫吸附试验抑制试验。这个 选择的过敏原有：猫、狗螨、豚草和马尾草。 其他被认为与特应性疾病风险相关的变量； 烟草烟雾暴露、喂食史和呼吸系统 感染，也将进行研究，以确定是否有或 这些变量对吸入性过敏的风险贡献更大。 而不是过敏原暴露的强度。烟草烟雾暴露 将通过测量尿可替宁浓度来定量 每两个月一次。儿童的喂养史和 呼吸系统疾病将在每月访谈期间记录下来 以标准化的方式。过敏症的发病和程度 敏感度将通过测量血清来确定。 过敏原特异性IgE浓度，至相同的五个 每六个月检查一次过敏原。 收集的数据将被分析以确定强度是否 暴露于过敏原是导致 一种遗传易感人群的变态反应致敏研究进展 人口。我们还将检查是否存在一个关键的 暴露强度，低于该强度敏化不太可能 是否发生以及暴露的强度和程度 敏化作用是相关的。这些问题的答案 应该表明环境控制的程度 这些措施可以降低过敏反应的风险。这 信息在减少上升的努力中是重要的 哮喘和其他过敏性疾病在儿童中的流行情况。

The purpose of this research is to prospectively evaluated the relationship between the intensity of airborne allergen exposure and the development of allergic sensitivity (production of allergen specific IgE) in a cohort of 80 children followed from birth to four years of age. The children selected for study will have a high genetic risk of atopy based on an elevated cord blood IgE concentration of greater than or equal to 0.6 u/ml. The quantities of the five inhalant allergens, to which young children most commonly become sensitized, will be measured in monthly air samples from each child's bedroom using a small volumetric air sampler, and an ELISA inhibition assay. The allergens selected are: cat, dog mite, ragweed, and timothery. Other variables thought to be related to the risk of atopy; tobacco smoke exposure, feeding history, and respiratory infections, will also be studied to determine whether any or these variables contribute more to the risk of inhalant allergy than intensity of allergen exposure. Tobacco smoke exposure will be quantitated by measuring urinary cotinine concentrations every two months. The child's feeding history and history of respiratory illnesses will be recorded during monthly interviews in a standardized fashion. The onset and degree of allergic sensitization will be determined by measuring serum concentrations of allergen specific IgE, to the same five allergens every six months. The data collected will be analyzed to determine if the intensity of allergen exposure is the most important risk factor for the development of allergic sensitization in a genetically susceptible population. We will also examine whether there is a critical intensity of exposure below which sensitization is unlikely to occur and whether the intensity of exposure and degree of sensitization are correlated. The answers to these questions should suggest the degree to which environmental control measures could reduced the risk of allergic sensitization. This information is important in the effort to reduce the rising prevalence of asthma and other allergic diseases among children.