TOTAL SURGICAL REPLACEMENT OF THE HUMAN HIP JOINT

这项建议是针对利用多孔材料进行骨骼固定的研究。 金属复合材料。具体地说，建议研究离子金属 多孔介质中的释放、传输现象及相关的系统效应 铸造钴铬(ASTM F-75)烧结粉末复合材料，锻造 钴镍铬钼(ASTM F-562)和Ti6A14V(ASTMF-136) 合金。相关的有机金属络合物将被分离并其 使用体外成纤维细胞培养进行毒性评估。这也是为了 评价多孔烧结粉末钴的致癌风险 铬复合材料(ASTM F-75)和变形钴镍铬钼 (ASTM F-562也称为MP35N)有固体、粉末和多孔形式。这个 纤维钛复合材料增强骨长入的可能性 羟基磷灰石、磷酸三钙、氟化物、骨髓的应用 含量、骨形态发生蛋白和直流电 将对刺激进行评估。还提出了比较两种方法的能力。 三种不同的钛多孔结构：纤维钛 作为完全或部分涂层的复合材料和作为 全髋关节假体的固定方法。骨骼的能力 重塑及其对周围皮质的相关影响将是 已评估。半球形设计的髋臼假体也将被 评估其作为骨移植手段的骨向内生长的潜力 定格。

This proposal is directed to the study of skeletal fixation using porous metallic composites. Specifically, it is proposed to study the ion metal release, transport phenomenon, and related systemic effects in porous sintered powder composites of cast cobalt chrome (ASTM F-75), wrought cobalt nickel chromiun molybdenum (ASTM F-562), and Ti6A14V (ASTMF-136) alloys. The related organometallic complexes will be isolated and their toxicity assessed using in vitro fibroblast cultures. It is also intended to evaluate the tumor induction risk of porous sintered powder cobalt chrome composite (ASTM F-75) and wrought cobalt-nickel-chromiun-molybdenum (ASTM F-562 also known as MP35N) in solid, powder and porous form. The possibility of bone ingrowth enhancement into fiber titanium composites by the use of hydroxyapatites, tricalcium phosphate, fluorides, bone marrow contents, bone morphogenetic protein and direct current electrical stimulation will be evaluated. It is also proposed to compare the ability of three different titanium porous configurations: fiber titanium composite as a total or partial coating and sintered titanium spheres as a method of fixation of a total hip prosthesis. The ability of bone to remodel and their related effects on the surrounding cortex will be evaluated. An acetabular prosthesis of a hemispherical design will also be evaluated in terms of its potential for bone ingrowth as a means of fixation.