Mixing the jigsaw pieces of natural products: new molecules-new properties

该项目旨在研究利用细菌生物合成机制快速获取天然产品类似物的能力。由于耐药性增加，需要新的天然产物储库作为未来药物进行评估。去铁胺B将被用作模型天然产物，以在补充有不饱和、氟化或氘代结构单元的细菌培养物中建立新类似物的生物合成。预期的成果是提供方法的进步，用于产生结构多样的天然产物池，新的无标记探针，天然产物生物合成的知识，并在培养研究生在化学生物学和药物发现的前沿方法卓越。

This project aims to examine the capacity of exploiting the bacterial biosynthetic machinery to fast-track access to analogues of natural products. Due to increased drug resistance, new reservoirs of natural products are needed for evaluation as future drugs. Desferrioxamine B will be used as a model natural product to establish the biosynthesis of new analogues in bacterial culture supplemented with unsaturated, fluorinated or deuterated building blocks. The intended outcomes are to deliver advances in methods for generating structurally diverse pools of natural products, new label-free probes, knowledge of natural product biosynthesis, and excellence in training research students in frontier methods in chemical biology and drug discovery.