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MUSCLE SATELLITE CELL: REACTION TO DISEASE AND TRAUMA

MUSCLE SATELLITE CELL: REACTION TO DISEASE AND TRAUMA
肌肉卫星细胞：对疾病和创伤的反应
批准号：
3157541
负责人：
Marcia R. Ontell
金额：
$10.76万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
项目状态：
已结题
起止时间：
1986-01-01 至 1988-12-31
来源：
https://reporter.nih.gov/project-details/3157541
关键词：
animal age group autoradiography bromodeoxyuridine cell growth regulation cell population study cellular pathology computer data analysis denervation disease /disorder model electron microscopy histopathology muscle cells muscle pharmacology muscle proteins muscular dystrophy musculoskeletal regeneration mutant myogenesis postpartum tissue /cell preparation trauma

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中文摘要
翻译
建议对肌肉卫星细胞进行深入研究，重点是 目标如下：1.卫星的形态和分布 新生儿肌肉中的细胞。2.病理效应的测定 突起和创伤(营养不良和失神经)的数量和 肌肉卫星细胞的超微结构。3.卫星小区比较 营养不良和正常肌肉发生和生长的动力学。4. 退变过程中卫星细胞起源和去向的研究 再生肌肉。5.卫星细胞在中国的意义分析 肌肉营养不良症。 两个基因突变小鼠品系(C57BL/6J-dy2J和C57BL/6J-dy2J)的体内研究 129/Re-dy)将使用光学和电子显微镜和光 显微放射自显影。
英文摘要
It is proposed to study in depth, the muscle satellite cells, with emphasis on the following objectives: 1. The morphology and distribution of satellite cells in neonatal muscle. 2. Determination of the effect of pathologic processes and trauma (dystrophy and denervation) on the quantity and ultrastructure of muscle satellite cells. 3. Comparison of satellite cell dynamics in myogenesis and growth of dystrophic and normal muscle. 4. Investigation of the origin and fate of satellite cells in degenerating and regenerating muscle. 5. Analysis of the significance of the satellite cell in muscular dystrophy. In vivo studies of two genetic mutant mouse strains (C57BL/6J-dy2J and 129/Re-dy) will be carried out using light and electron microscopy and light microscopic radioautography.
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MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
MYOGENIC FACTORS: MUSCLE MATURATION AND REGENERATION
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