Synthetic RNA designs for defective virus vaccines of African horse sickness disease

非洲马病是一种马的病毒性疾病，在naïve导致高达90%的死亡率，但也可以感染作为宿主的其他动物（骡子、驴、斑马、山羊）而没有严重的疾病症状。AHSV是撒哈拉以南非洲的地方病，但在西班牙和葡萄牙偶尔爆发了这种疾病，造成了重大的社会和经济影响。这种病毒通过叮咬在整个欧洲和英国发现的蠓传播，增加了爆发的潜在风险。随着气候变化影响到这些蠓的总体数量和它们的传播，这正成为一个更大的问题。目前有针对AHSV的疫苗，但它们被认为是不安全的，会产生不良副作用，并有可能将不同类型的病毒释放到环境中。这一提议将开发出高度安全的疫苗，并将保护动物免受感染而没有副作用。由于LSHTM的一个研究小组最近的发现，新疫苗才有可能出现，并且将使用其他公共或商业组织尚未提供的技术。

African horse sickness is a viral disease of horses that results in up to 90% death in naïve but can also infect without severe disease symptom other animals (mules, donkeys, zebras, goats), which act as reservoir. AHSV is endemic to the sub-Saharan Africa but there has been the occasional outbreak of the disease in Spain and Portugal which had significant social and economic impact. The virus is spread by biting midges that are found throughout Europe and the UK, increasing the potential risk of an outbreak. This is becoming a greater concern as climate changes influence both the overall populations of these midges and their dispersal. There are current vaccines available for AHSV but they are considered unsafe, causing adverse side effects and have potential for releasing different type of the viruses into the environment. This proposal will develop vaccines that will be highly safe and will protect the animals from infection without the side effects. The new vaccines are only possible due to recent discoveries made by a research team at the LSHTM, and will use technologies, which are not yet available in other public or commercial organizations.