RADIATION REPAIR OF NORMAL MAMMALIAN TISSUES

本研究旨在定量评估 微血管和其他犬正常组织单独接受辐射， 与其他代理商的组合。 特别感兴趣的是确定 高线性能量传递（LET）的相对生物学效应（RBE） 辐射，以及潜在的修复亚致命辐射的能力丧失， 高LET辐射或低LET辐射组合造成的辐射损伤 和其他探员 多分割照射将允许测量 每部分的修复量。 多个馏分的RBE计算将 基于根据剂量反应确定的引起等效应所需的剂量 通过照射到相同数量的可变剂量获得的曲线 60 Co γ辐射和π介子或中子辐射的分数。 微血管研究将在这项工作中得到强调;然而， 将评估心脏对辐射的影响，随着技术的发展， 和脊髓。 微血管系统的反应将是 60 Co γ辐射单次和多次剂量的测定 辐射防护剂WR-2721和癌症化疗剂 兴趣 心脏对各种照射方法的反应将是 通过血清蛋白，血清同工酶， 放射照相术、超声心动图和心电图。 形态测定分析 心肌的解剖 在整个研究过程中， 将测试值的早期变化与观察到的辐射效应相关联 后 一些测试可能是晚期并发症的早期指标。

This research is intended to evaluate quantitatively the response of microvasculature and other canine normal tissues to radiation alone, and in combination with other agents. Of specific interest are the determination of the relative biological effectiveness (RBE) of high linear energy transfer (LET) radiations, and the potential loss of capability for repair of sublethal radiation damage from high LET radiations or low LET radiations in combination with other agents. Multifraction irradiation will permit measurement of the amount of repair per fraction. Calculations of RBE for multiple fractions will be based on doses required to cause an isoeffect determined from dose response curves obtained by irradiation to variable doses given in an equal number of fractions for 60Co gamma radiation and pion or neutron irradiation. Microvascular studies will be emphasized in this work; however, response of the heart to irradiation will be evaluated, and as techniques are developed, brain and spinal cord will be included. The response of the microvasculature will be determined for single and multifraction doses of 60Co gamma radiation combined with heat, the radioprotector WR-2721 and cancer chemotherapeutic agents of interest. The response of the heart to various methods of irradiation will be compared by sequential evaluations of serum protein, serum isoenzymes, radiography, echocardiography, and electrocardiography. Morphometric analysis of the myocardium will be done. Throughout this research, efforts will be made to correlate early alterations in test values with radiation effects observed later. Some of the tests may be early indicators of late complications.