RELATION OF BENIGN HYPERPLASIA TO CARCINOMA OF PROSTATE

本研究的长期目标是发展对 前列腺增生与前列腺癌的关系 的 主要具体目标是评估前列腺癌死亡率 经病理证实的BPH发生率和前列腺 根据BPH的组织学特征确定癌症发病率和死亡率。 建议进行一项回顾性随访研究。 一个基于人口的群体， 将通过使用以下方法确定6，000名经病理证实的BPH男性 罗得岛州医院的病理学记录 受试者将 在1959年至1970年期间，他们的指数录取， 当时75岁以上。 该队列将通过使用 医疗记录，死亡证明，城市目录，以及其他现有的 资源 所有病例的良性组织切片将被取出 的前列腺癌，并为样本的3倍， 非案件数量。 将根据标准对幻灯片进行审查 为了评估增生组织的特征， 尤其是上皮成分和其他良性变化。 死亡 将队列中前列腺癌的发生率与 罗得岛同龄人经历过的。 通过使用 病例对照队列方法，发病率和死亡率 从前列腺癌将与组织学特征的 切除良性组织 其他原因造成的死亡率也将 评估。 这一发现将对前列腺疾病的自然史产生影响。 增生，并对这种情况下的男性的临床预后。

The long-term goal of this study is to develop knowledge of the relationship of prostatic hyperplasia (BPH) and prostatic cancer. The principal specific aims are evaluation of the prostatic cancer mortality rate subsequent to surgically-confirmed BPH and comparison of prostatic cancer incidence and death rates according to histologic features of BPH. A retrospective follow-up study is proposed. A population-based group of 6,000 men with surgically-confirmed BPH will be identified by use of pathology records in Rhode Island hospitals state-wide. Subjects will have had their index admission in the period 1959-70, and will have been less than 75 years old at that time. The cohort will be followed up by use of medical records, death certificates, city directories, and other existing resources. Slides of the benign tissue will be retrieved for all the cases of prostatic cancer that are identified, and for a sample of 3 times that number of non-cases. The slides will be reviewed according to a standard protocol in order to assess the features of the hyperplastic tissue, especially the epithelial component, and other benign changes. The death rate from prostatic cancer in the cohort will be compared to the rate experienced by Rhode Island men of similar ages. By use of the case-control within a cohort approach, the incidence and mortality rates from prostatic cancer will be correlated with histologic features of the benign tissue removed. Death rates from other causes also will be evaluated. The findings will bear on the natural history of prostatic hyperplasia, and on the clinical prognosis of men with this condition.