RELATION OF BENIGN HYPERPLASIA TO CARCINOMA OF PROSTATE

这项研究的长期目标是发展对 前列腺增生症与前列腺癌的关系这个 主要的特定目标是评估前列腺癌的死亡率。 经手术证实的良性前列腺增生症的发生率和前列腺癌的比较 根据前列腺增生症的组织学特征进行肿瘤发生率和死亡率的研究。 建议进行一项回顾性的随访研究。一群以人口为基础的 6,000名经手术证实的前列腺增生症患者将通过使用 罗德岛全州医院的病理记录。受试者将拥有 在1959-70年期间有他们的指数录取，而且将会更少 比当时的75岁还多。该队列将通过使用 医疗记录、死亡证明、城市名录和其他现有的 资源。所有病例的良性组织切片都将被取回 前列腺癌的风险，以及3倍的样本 非病例数。幻灯片将根据一个标准进行审查 为了评估增生性组织的特征， 尤其是上皮成分等良性病变。死亡 队列中前列腺癌的发病率将与 罗德岛上年龄相仿的男人都有过这种经历。通过使用 队列方法中的病例对照、发病率和死亡率 前列腺癌的组织学特征将与前列腺癌相关 良性组织被摘除。其他原因的死亡率也将是 已评估。这些发现将与前列腺癌的自然历史有关。 以及对患有这种疾病的男性的临床预后的影响。

The long-term goal of this study is to develop knowledge of the relationship of prostatic hyperplasia (BPH) and prostatic cancer. The principal specific aims are evaluation of the prostatic cancer mortality rate subsequent to surgically-confirmed BPH and comparison of prostatic cancer incidence and death rates according to histologic features of BPH. A retrospective follow-up study is proposed. A population-based group of 6,000 men with surgically-confirmed BPH will be identified by use of pathology records in Rhode Island hospitals state-wide. Subjects will have had their index admission in the period 1959-70, and will have been less than 75 years old at that time. The cohort will be followed up by use of medical records, death certificates, city directories, and other existing resources. Slides of the benign tissue will be retrieved for all the cases of prostatic cancer that are identified, and for a sample of 3 times that number of non-cases. The slides will be reviewed according to a standard protocol in order to assess the features of the hyperplastic tissue, especially the epithelial component, and other benign changes. The death rate from prostatic cancer in the cohort will be compared to the rate experienced by Rhode Island men of similar ages. By use of the case-control within a cohort approach, the incidence and mortality rates from prostatic cancer will be correlated with histologic features of the benign tissue removed. Death rates from other causes also will be evaluated. The findings will bear on the natural history of prostatic hyperplasia, and on the clinical prognosis of men with this condition.