RESIDUAL RADIATION DAMAGE IN NORMAL TISSUES

拟议研究的总体目标是衡量 四种正常组织的记忆剂量衰减率 照射后不同时间的损伤与晚期纤维化 在其中三个组织中有反应。更具体地说，这些研究将 关注皮肤和肠道的急性反应，晚期反应 肺和肾，以及较晚出现的肠(狭窄)、肺损害 (纤维化)和皮肤(收缩)。调查将继续进行。 在使用成熟的放射生物学技术的小鼠身上。这些研究 应该增加我们对耗尽的动力学的理解 急性和迟发性反应正常的靶细胞的再繁殖 对于所有受辐射的组织和后期纤维化波的共同损害 正常组织，以及提供洞察基本过程 组织对损伤的反应。这些研究的潜在重要性 临床放射治疗是他们应该为放射治疗师提供 复治时设计治疗方案的指南 以前受过照射的部位是必需的。

The general objective of the proposed research is to measure the extent and rate of decay of remembered dose in four normal tissues that express their injury at different times after irradiation and for the late fibrotic response in three of the tissues. More specifically, these studies will focus on the acute response in skin and intestine, the late response in lung and kidney, and the later appearing damage in bowel (stenosis), lung (fibrosis), and skin (contraction). The investigations will be carried ut in mice using well established radiobiological techniques. These studies should increase our understanding of the kinetics of depletion and repopulation of the target cells for acutely and late responding normal tissues and for the later fibrotic wave of damage common to all irradiated normal tissues, as well as provide insight into fundamental processes of tissue response to injury. The potential importance of these studies to clinical radiotherapy is that they should provide radiotherapists with guidelines for designing treatment protocols when retreatment of a previously irradiated site is necessary.