TOTAL SYNTHESIS OF APHIDICOLN, A POTENT ANTITUMOR AGENT

这项研究的目的是开发一种综合方法学，涉及一种 新的双迈克尔环化和手性转移将允许 抗肿瘤药物Aphidicolin将以高效的方式合成。 该项目的成功完成将为 生产充足的这种有希望的新药，以及 提供可用于测试的合成类似物 抗肿瘤和抗有丝分裂药。该项目旨在提供新的 综合方法论将在以下领域具有普遍用途 化学合成。

The aim of this research is to develop synthetic methodology involving a new double Michael cyclization and chirality transfer which will allow the antitumor agent Aphidicolin to be synthesized in an efficient manner. Successful completion of this project will provide a method for the production of an abundant supply of this promising new drug, as well as providing synthetic analogs which will be available for testing as antitumor and antimitotic agents. This project is designed to provide new synthetic methodology which will be of general utility in the field of chemical synthesis.